@inbook{87a2b3e4f2c64e0581bccd138eaa6a69,
title = "MRI Methods for Imaging Beta-Cell Function in the Rodent Pancreas",
abstract = "The role of Zn2+ ions in proper storage of insulin in β-cell granules is well-established so when insulin is secreted from β-cells stimulated by an increase in plasma glucose, free Zn2+ ions are also released. This local increase in Zn2+ can be detected in the pancreas of rodents in real time by the use of a zinc-responsive MR contrast agent. This method offers the opportunity to monitor β-cell function longitudinally in live rodents. The methods used in our lab are fully described in this short report and some MR images of a rat pancreas showing clearly enhanced hot spots in the tail are presented.",
keywords = "Functional imaging, Glucose-stimulated insulin secretion (GSIS), Glucose-stimulated zinc secretion (GSZS), Imaging β-cell function in vivo, MRI, Rodent models, Zinc-responsive agents",
author = "Pooyan Khalighinejad and Suh, {Eul Hyun} and Sherry, {A. Dean}",
note = "Funding Information: The authors gratefully acknowledge the financial support from the National Institutes of Health (NIH; grant DK-095416) and valuable input from Dr. Xiaodong Wen and Dr. Shanrong Zhang. Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2023",
doi = "10.1007/978-1-0716-2807-2_7",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "101--111",
booktitle = "Methods in Molecular Biology",
}