MRI Methods for Imaging Beta-Cell Function in the Rodent Pancreas

Pooyan Khalighinejad, Eul Hyun Suh, A. Dean Sherry

Research output: Chapter in Book/Report/Conference proceedingChapter


The role of Zn2+ ions in proper storage of insulin in β-cell granules is well-established so when insulin is secreted from β-cells stimulated by an increase in plasma glucose, free Zn2+ ions are also released. This local increase in Zn2+ can be detected in the pancreas of rodents in real time by the use of a zinc-responsive MR contrast agent. This method offers the opportunity to monitor β-cell function longitudinally in live rodents. The methods used in our lab are fully described in this short report and some MR images of a rat pancreas showing clearly enhanced hot spots in the tail are presented.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages11
StatePublished - 2023

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029


  • Functional imaging
  • Glucose-stimulated insulin secretion (GSIS)
  • Glucose-stimulated zinc secretion (GSZS)
  • Imaging β-cell function in vivo
  • MRI
  • Rodent models
  • Zinc-responsive agents

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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