MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)8-dendron for targeting

Luis M. De León-Rodríguez; Angelo Lubag; D. Gomika Udugamasooriya; Bettina Proneth; Rolf A. Brekken; Xiankai Sun; Thomas Kodadek; A. Dean Sherry

doi:10.1021/ja105563a

MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)₈-dendron for targeting

Luis M. De León-Rodríguez, Angelo Lubag, D. Gomika Udugamasooriya, Bettina Proneth, Rolf A. Brekken, Xiankai Sun, Thomas Kodadek, A. Dean Sherry

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

The synthesis of a polylysine dendron containing eight GdDOTA units conjugated to a peptoid dimer known to have a high affinity for the vascular endothelial growth factor receptor 2 (VEGFR2) is described. This simple low molecular weight system with a molecular r₁ relaxivity of ∼48 mM^-1 s^-1 is shown to enhance MR images of tumors grown in mice in vivo.

Original language	English (US)
Pages (from-to)	12829-12831
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	132
Issue number	37
DOIs	https://doi.org/10.1021/ja105563a
State	Published - Sep 22 2010

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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abstract = "The synthesis of a polylysine dendron containing eight GdDOTA units conjugated to a peptoid dimer known to have a high affinity for the vascular endothelial growth factor receptor 2 (VEGFR2) is described. This simple low molecular weight system with a molecular r1 relaxivity of ∼48 mM-1 s-1 is shown to enhance MR images of tumors grown in mice in vivo.",

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AU - De León-Rodríguez, Luis M.

AU - Lubag, Angelo

AU - Udugamasooriya, D. Gomika

AU - Proneth, Bettina

AU - Brekken, Rolf A.

AU - Sun, Xiankai

AU - Kodadek, Thomas

AU - Dean Sherry, A.

PY - 2010/9/22

Y1 - 2010/9/22

N2 - The synthesis of a polylysine dendron containing eight GdDOTA units conjugated to a peptoid dimer known to have a high affinity for the vascular endothelial growth factor receptor 2 (VEGFR2) is described. This simple low molecular weight system with a molecular r1 relaxivity of ∼48 mM-1 s-1 is shown to enhance MR images of tumors grown in mice in vivo.

AB - The synthesis of a polylysine dendron containing eight GdDOTA units conjugated to a peptoid dimer known to have a high affinity for the vascular endothelial growth factor receptor 2 (VEGFR2) is described. This simple low molecular weight system with a molecular r1 relaxivity of ∼48 mM-1 s-1 is shown to enhance MR images of tumors grown in mice in vivo.

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JF - Journal of the American Chemical Society

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ER -

MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)₈-dendron for targeting

Abstract

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