The synthesis of a polylysine dendron containing eight GdDOTA units conjugated to a peptoid dimer known to have a high affinity for the vascular endothelial growth factor receptor 2 (VEGFR2) is described. This simple low molecular weight system with a molecular r1 relaxivity of ∼48 mM-1 s-1 is shown to enhance MR images of tumors grown in mice in vivo.
ASJC Scopus subject areas
- General Chemistry
- Colloid and Surface Chemistry