Mri-derived restriction spectrum imaging cellularity index is associated with high grade prostate cancer on radical prostatectomy specimens

Michael A. Liss; Nathan S. White; J. Kellogg Parsons; Natalie M. Schenker-Ahmed; Rebecca Rakow-Penner; Joshua M. Kuperman; Hauke Bartsch; Hyung W. Choi; Robert F. Mattrey; William G. Bradley; Ahmed Shabaik; Jiaoti Huang; Daniel J.A. Margolis; Steven S. Raman; Leonard S. Marks; Christopher J. Kane; Robert E. Reiter; Anders M. Dale; David S. Karow

doi:10.3389/fonc.2015.00030

Mri-derived restriction spectrum imaging cellularity index is associated with high grade prostate cancer on radical prostatectomy specimens

Michael A. Liss, Nathan S. White, J. Kellogg Parsons, Natalie M. Schenker-Ahmed, Rebecca Rakow-Penner, Joshua M. Kuperman, Hauke Bartsch, Hyung W. Choi, Robert F. Mattrey, William G. Bradley, Ahmed Shabaik, Jiaoti Huang, Daniel J.A. Margolis, Steven S. Raman, Leonard S. Marks, Christopher J. Kane, Robert E. Reiter, Anders M. Dale, David S. Karow

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Abstract

Purpose: We evaluate a novel magnetic resonance imaging (MRI) technique to improve detection of aggressive prostate cancer (PCa). Materials and Methods: We performed a retrospective analysis of pre-surgical prostate MRI scans using an advanced diffusion-weighted imaging technique called restriction spectrum imaging (RSI), which can be presented as a normalized z-score statistic. Scans were acquired prior to radical prostatectomy. Prostatectomy specimens were processed using whole-mount sectioning and regions of interest (ROIs) were drawn around individual PCa tumors. Corresponding ROIs were drawn on the MRI imaging and paired with ROIs in regions with no pathology. RSI z-score and conventional apparent diffusion coefficient (ADC) values were recorded for each ROI. Paired t-test, ANOVA, and logistic regression analyses were performed. Results: We evaluated 28 patients with 64 ROIs (28 benign and 36 PCa). The mean difference in RSI z-score (PCa ROI-Benign ROI) was 2.17 (SE = 0.11; p < 0.001) and in ADC was 551 mm²/s (SE = 80 mm²/s; paired t-test, p < 0.001). The differences in the means among all groups (benign, primary Gleason 3, and primary Gleason 4) was significant for both RSI z-score (F_3,64 = 97.7, p < 0.001) and ADC (F_3,64 = 13.9, p < 0.001). A t-test was performed on only PCa tumor ROIs (n = 36) to determine PCa aggressiveness (Gleason 3 vs. Gleason 4) revealing that RSI z-score was still significant (p = 0.03), whereas, ADC values were no longer significant (p = 0.08). In multivariable analysis adjusting for age and race, RSI z-score was associated with PCa aggressiveness (OR 10.3, 95% CI: 1.4-78.0, p = 0.02) while ADC trended to significance (p = 0.07). Conclusion: The RSI-derived normalized cellularity index is associated with aggressive PCa as determined by pathologic Gleason scores. Further utilization of RSI techniques may serve to enhance standardized reporting systems for PCa in the future.

Original language	English (US)
Article number	30
Journal	Frontiers in Oncology
Volume	5
Issue number	FEB
DOIs	https://doi.org/10.3389/fonc.2015.00030
State	Published - 2015

Keywords

Cellularity
Gleason score
MRI imaging
Prostate
Prostate cancer

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3389/fonc.2015.00030

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Liss, M. A., White, N. S., Parsons, J. K., Schenker-Ahmed, N. M., Rakow-Penner, R., Kuperman, J. M., Bartsch, H., Choi, H. W., Mattrey, R. F., Bradley, W. G., Shabaik, A., Huang, J., Margolis, D. J. A., Raman, S. S., Marks, L. S., Kane, C. J., Reiter, R. E., Dale, A. M., & Karow, D. S. (2015). Mri-derived restriction spectrum imaging cellularity index is associated with high grade prostate cancer on radical prostatectomy specimens. Frontiers in Oncology, 5(FEB), Article 30. https://doi.org/10.3389/fonc.2015.00030

Liss, MA, White, NS, Parsons, JK, Schenker-Ahmed, NM, Rakow-Penner, R, Kuperman, JM, Bartsch, H, Choi, HW, Mattrey, RF, Bradley, WG, Shabaik, A, Huang, J, Margolis, DJA, Raman, SS, Marks, LS, Kane, CJ, Reiter, RE, Dale, AM & Karow, DS 2015, 'Mri-derived restriction spectrum imaging cellularity index is associated with high grade prostate cancer on radical prostatectomy specimens', Frontiers in Oncology, vol. 5, no. FEB, 30. https://doi.org/10.3389/fonc.2015.00030

@article{5b5b8f4c8baf4908b6a0d151e8b80494,

title = "Mri-derived restriction spectrum imaging cellularity index is associated with high grade prostate cancer on radical prostatectomy specimens",

abstract = "Purpose: We evaluate a novel magnetic resonance imaging (MRI) technique to improve detection of aggressive prostate cancer (PCa). Materials and Methods: We performed a retrospective analysis of pre-surgical prostate MRI scans using an advanced diffusion-weighted imaging technique called restriction spectrum imaging (RSI), which can be presented as a normalized z-score statistic. Scans were acquired prior to radical prostatectomy. Prostatectomy specimens were processed using whole-mount sectioning and regions of interest (ROIs) were drawn around individual PCa tumors. Corresponding ROIs were drawn on the MRI imaging and paired with ROIs in regions with no pathology. RSI z-score and conventional apparent diffusion coefficient (ADC) values were recorded for each ROI. Paired t-test, ANOVA, and logistic regression analyses were performed. Results: We evaluated 28 patients with 64 ROIs (28 benign and 36 PCa). The mean difference in RSI z-score (PCa ROI-Benign ROI) was 2.17 (SE = 0.11; p < 0.001) and in ADC was 551 mm2/s (SE = 80 mm2/s; paired t-test, p < 0.001). The differences in the means among all groups (benign, primary Gleason 3, and primary Gleason 4) was significant for both RSI z-score (F3,64 = 97.7, p < 0.001) and ADC (F3,64 = 13.9, p < 0.001). A t-test was performed on only PCa tumor ROIs (n = 36) to determine PCa aggressiveness (Gleason 3 vs. Gleason 4) revealing that RSI z-score was still significant (p = 0.03), whereas, ADC values were no longer significant (p = 0.08). In multivariable analysis adjusting for age and race, RSI z-score was associated with PCa aggressiveness (OR 10.3, 95% CI: 1.4-78.0, p = 0.02) while ADC trended to significance (p = 0.07). Conclusion: The RSI-derived normalized cellularity index is associated with aggressive PCa as determined by pathologic Gleason scores. Further utilization of RSI techniques may serve to enhance standardized reporting systems for PCa in the future.",

keywords = "Cellularity, Gleason score, MRI imaging, Prostate, Prostate cancer",

author = "Liss, {Michael A.} and White, {Nathan S.} and Parsons, {J. Kellogg} and Schenker-Ahmed, {Natalie M.} and Rebecca Rakow-Penner and Kuperman, {Joshua M.} and Hauke Bartsch and Choi, {Hyung W.} and Mattrey, {Robert F.} and Bradley, {William G.} and Ahmed Shabaik and Jiaoti Huang and Margolis, {Daniel J.A.} and Raman, {Steven S.} and Marks, {Leonard S.} and Kane, {Christopher J.} and Reiter, {Robert E.} and Dale, {Anders M.} and Karow, {David S.}",

note = "Publisher Copyright: {\textcopyright} 2015 Liss, White, Parsons, Schenker-Ahmed, Rakow-Penner, Kuperman, Bartsch, Choi, Mattrey, Bradley, Shabaik, Huang, Margolis, Raman, Marks, Kane, Reiter, Dale and Karow.",

year = "2015",

doi = "10.3389/fonc.2015.00030",

language = "English (US)",

volume = "5",

journal = "Frontiers in Oncology",

issn = "2234-943X",

publisher = "Frontiers Media S. A.",

number = "FEB",

}

TY - JOUR

T1 - Mri-derived restriction spectrum imaging cellularity index is associated with high grade prostate cancer on radical prostatectomy specimens

AU - Liss, Michael A.

AU - White, Nathan S.

AU - Parsons, J. Kellogg

AU - Schenker-Ahmed, Natalie M.

AU - Rakow-Penner, Rebecca

AU - Kuperman, Joshua M.

AU - Bartsch, Hauke

AU - Choi, Hyung W.

AU - Mattrey, Robert F.

AU - Bradley, William G.

AU - Shabaik, Ahmed

AU - Huang, Jiaoti

AU - Margolis, Daniel J.A.

AU - Raman, Steven S.

AU - Marks, Leonard S.

AU - Kane, Christopher J.

AU - Reiter, Robert E.

AU - Dale, Anders M.

AU - Karow, David S.

PY - 2015

Y1 - 2015

N2 - Purpose: We evaluate a novel magnetic resonance imaging (MRI) technique to improve detection of aggressive prostate cancer (PCa). Materials and Methods: We performed a retrospective analysis of pre-surgical prostate MRI scans using an advanced diffusion-weighted imaging technique called restriction spectrum imaging (RSI), which can be presented as a normalized z-score statistic. Scans were acquired prior to radical prostatectomy. Prostatectomy specimens were processed using whole-mount sectioning and regions of interest (ROIs) were drawn around individual PCa tumors. Corresponding ROIs were drawn on the MRI imaging and paired with ROIs in regions with no pathology. RSI z-score and conventional apparent diffusion coefficient (ADC) values were recorded for each ROI. Paired t-test, ANOVA, and logistic regression analyses were performed. Results: We evaluated 28 patients with 64 ROIs (28 benign and 36 PCa). The mean difference in RSI z-score (PCa ROI-Benign ROI) was 2.17 (SE = 0.11; p < 0.001) and in ADC was 551 mm2/s (SE = 80 mm2/s; paired t-test, p < 0.001). The differences in the means among all groups (benign, primary Gleason 3, and primary Gleason 4) was significant for both RSI z-score (F3,64 = 97.7, p < 0.001) and ADC (F3,64 = 13.9, p < 0.001). A t-test was performed on only PCa tumor ROIs (n = 36) to determine PCa aggressiveness (Gleason 3 vs. Gleason 4) revealing that RSI z-score was still significant (p = 0.03), whereas, ADC values were no longer significant (p = 0.08). In multivariable analysis adjusting for age and race, RSI z-score was associated with PCa aggressiveness (OR 10.3, 95% CI: 1.4-78.0, p = 0.02) while ADC trended to significance (p = 0.07). Conclusion: The RSI-derived normalized cellularity index is associated with aggressive PCa as determined by pathologic Gleason scores. Further utilization of RSI techniques may serve to enhance standardized reporting systems for PCa in the future.

AB - Purpose: We evaluate a novel magnetic resonance imaging (MRI) technique to improve detection of aggressive prostate cancer (PCa). Materials and Methods: We performed a retrospective analysis of pre-surgical prostate MRI scans using an advanced diffusion-weighted imaging technique called restriction spectrum imaging (RSI), which can be presented as a normalized z-score statistic. Scans were acquired prior to radical prostatectomy. Prostatectomy specimens were processed using whole-mount sectioning and regions of interest (ROIs) were drawn around individual PCa tumors. Corresponding ROIs were drawn on the MRI imaging and paired with ROIs in regions with no pathology. RSI z-score and conventional apparent diffusion coefficient (ADC) values were recorded for each ROI. Paired t-test, ANOVA, and logistic regression analyses were performed. Results: We evaluated 28 patients with 64 ROIs (28 benign and 36 PCa). The mean difference in RSI z-score (PCa ROI-Benign ROI) was 2.17 (SE = 0.11; p < 0.001) and in ADC was 551 mm2/s (SE = 80 mm2/s; paired t-test, p < 0.001). The differences in the means among all groups (benign, primary Gleason 3, and primary Gleason 4) was significant for both RSI z-score (F3,64 = 97.7, p < 0.001) and ADC (F3,64 = 13.9, p < 0.001). A t-test was performed on only PCa tumor ROIs (n = 36) to determine PCa aggressiveness (Gleason 3 vs. Gleason 4) revealing that RSI z-score was still significant (p = 0.03), whereas, ADC values were no longer significant (p = 0.08). In multivariable analysis adjusting for age and race, RSI z-score was associated with PCa aggressiveness (OR 10.3, 95% CI: 1.4-78.0, p = 0.02) while ADC trended to significance (p = 0.07). Conclusion: The RSI-derived normalized cellularity index is associated with aggressive PCa as determined by pathologic Gleason scores. Further utilization of RSI techniques may serve to enhance standardized reporting systems for PCa in the future.

KW - Cellularity

KW - Gleason score

KW - MRI imaging

KW - Prostate

KW - Prostate cancer

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U2 - 10.3389/fonc.2015.00030

DO - 10.3389/fonc.2015.00030

M3 - Article

C2 - 25741473

AN - SCOPUS:84923253525

SN - 2234-943X

VL - 5

JO - Frontiers in Oncology

JF - Frontiers in Oncology

IS - FEB

M1 - 30

ER -

Mri-derived restriction spectrum imaging cellularity index is associated with high grade prostate cancer on radical prostatectomy specimens

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