TY - JOUR
T1 - MRI Assessment of Diastolic and Systolic Intraventricular Pressure Gradients in Heart Failure
AU - Jain, Snigdha
AU - Londono, Francisco J.
AU - Segers, Patrick
AU - Gillebert, Thierry C.
AU - De Buyzere, Marc
AU - Chirinos, Julio A.
N1 - Publisher Copyright:
© 2016, Springer Science+Business Media New York.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - A deep phenotypic characterization of heart failure (HF) is important for a better understanding of its pathophysiology. In particular, novel noninvasive techniques for the characterization of functional abnormalities in HF with preserved ejection fraction are currently needed. While echocardiography is widely used to assess ventricular function, standard echocardiographic techniques provide a limited understanding of ventricular filling. The application of fluid dynamics theory, along with assessments of flow velocity fields in multiple dimensions in the ventricle, can be used to assess intraventricular pressure gradients (IVPGs), which in turn may provide valuable insights into ventricular diastolic and systolic function. Advances in imaging techniques now allow for accurate estimations of systolic and diastolic IVPGs, using noninvasive methods that are easily applicable in clinical research. In this review, we describe the basic concepts regarding intraventricular flow measurements and the derivation of IVPGs. We also review existing literature exploring the role of IVPGs in HF.
AB - A deep phenotypic characterization of heart failure (HF) is important for a better understanding of its pathophysiology. In particular, novel noninvasive techniques for the characterization of functional abnormalities in HF with preserved ejection fraction are currently needed. While echocardiography is widely used to assess ventricular function, standard echocardiographic techniques provide a limited understanding of ventricular filling. The application of fluid dynamics theory, along with assessments of flow velocity fields in multiple dimensions in the ventricle, can be used to assess intraventricular pressure gradients (IVPGs), which in turn may provide valuable insights into ventricular diastolic and systolic function. Advances in imaging techniques now allow for accurate estimations of systolic and diastolic IVPGs, using noninvasive methods that are easily applicable in clinical research. In this review, we describe the basic concepts regarding intraventricular flow measurements and the derivation of IVPGs. We also review existing literature exploring the role of IVPGs in HF.
KW - Color M-mode
KW - Diastolic function
KW - Heart failure
KW - Heart failure and preserved ejection fraction
KW - Intraventricular pressure gradients
KW - Magnetic resonance imaging
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U2 - 10.1007/s11897-016-0281-0
DO - 10.1007/s11897-016-0281-0
M3 - Review article
C2 - 26780916
AN - SCOPUS:84958057810
SN - 1546-9530
VL - 13
SP - 37
EP - 46
JO - Current heart failure reports
JF - Current heart failure reports
IS - 1
ER -