TY - JOUR
T1 - MR imaging of papilledema and visual pathways
T2 - Effects of increased intracranial pressure and pathophysiologic mechanisms
AU - Passi, N.
AU - Degnan, A. J.
AU - Levy, L. M.
N1 - Funding Information:
and A. Cuellar for technical assistance, and C. Coffinier, E. Delot, J. I. Kim, J. Larraín, K. M. Lyons, M. Oelgeschläger, E. Pera, O. Wessely for discussions and comments on the manuscript. J.G.A. was a Latin American PEW fellow. This work was supported by the National Institutes of Health (R37 HD21502-16). E.M.D.R. is an Investigator of the Howard Hughes Medical Institute. Correspondence and requests for material should be addressed to E.M.D.R. Supplementary information is available on Nature Cell Biology’s website (http://cellbio.nature.com).
PY - 2013/5
Y1 - 2013/5
N2 - Papilledema, defined as swelling of the optic disc, frequently occurs in the setting of increased ICP and in a variety of medical conditions, including pseudotumor cerebri, sinus thrombosis, intracerebral hemorrhage, frontal lobe neoplasms, and Chiari malformation. Noninvasive imaging of the ON is possible by using MR imaging, with a variety of findings occurring in the setting of papilledema, including flattening of the posterior sclera, protrusion of the optic disc, widening of the ONS, and tortuosity of the ON. Early recognition of papilledema and elevated ICP is of paramount importance for ensuring restoration of vision. Newer advanced MR imaging techniques such as fMRI and DTI may prove useful in the future to assess the potential effects of papilledema on retinal and visual pathway integrity.
AB - Papilledema, defined as swelling of the optic disc, frequently occurs in the setting of increased ICP and in a variety of medical conditions, including pseudotumor cerebri, sinus thrombosis, intracerebral hemorrhage, frontal lobe neoplasms, and Chiari malformation. Noninvasive imaging of the ON is possible by using MR imaging, with a variety of findings occurring in the setting of papilledema, including flattening of the posterior sclera, protrusion of the optic disc, widening of the ONS, and tortuosity of the ON. Early recognition of papilledema and elevated ICP is of paramount importance for ensuring restoration of vision. Newer advanced MR imaging techniques such as fMRI and DTI may prove useful in the future to assess the potential effects of papilledema on retinal and visual pathway integrity.
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U2 - 10.3174/ajnr.A3022
DO - 10.3174/ajnr.A3022
M3 - Review article
C2 - 22422187
AN - SCOPUS:84878472281
SN - 0195-6108
VL - 34
SP - 919
EP - 924
JO - American Journal of Neuroradiology
JF - American Journal of Neuroradiology
IS - 5
ER -