The A9 cell line, frequently used for cell hybridization, is deficient in both HPRT and APRT. Evidently the parent L cell line from which A9 was derived had previously undergone a spontaneous mutation to APRT deficiency. The double enzyme deficiency in A9 cells should be recognized by investigators who use this line for studies on somatic cell genetics.
|Number of pages
|American Journal of Human Genetics
|Published - Jan 1 1974
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