TY - JOUR
T1 - Mortality and Morbidity Among Adult Liver Retransplant Recipients
AU - Dakroub, Ali
AU - Anouti, Ahmad
AU - Cotter, Thomas G.
AU - Lee, William M.
N1 - Funding Information:
The data reported in this study have been supplied by the Hennepin Healthcare Research Institute (HHRI) as the contractor for the Scientific Registry of Transplant Recipients (SRTR). The interpretation and reporting of these data are the responsibility of the author(s) and in no way should be seen as an official policy of or interpretation by the SRTR or the U.S. Government
Funding Information:
Dr. Lee is supported by U01 DK58369 and by research support from Intercept, Aurora, Gilead, Novo Nordisk, Alexion, Eiger, Camurus and Lipocine, and consults for Forma, SeaGen, GSK, Karuna, and Cortexyme. Dr. Cotter is supported by NIH grant U01 AA026975 and by the AASLD Clinical, Translational and Outcomes Research Awards in Liver Disease. Funding was provided by Southwestern Medical Foundation (Jeanne Roberts Fund).
Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023/10
Y1 - 2023/10
N2 - Background: Liver transplantation (LT) is life-saving procedure for patients with end-stage liver failure with up to 20% of patients suffering graft failure following primary transplantation. Retransplantation (ReLT) remains the only definitive treatment for irreversible graft failure. Aims: We aimed to explore the postoperative outcomes following liver ReLT. Methods: Patients who had received a liver transplant between 2003 and 2016 were retrospectively identified using the Scientific Registry of Transplant Recipients (SRTRs). Patients were stratified based on previous liver transplant history. The primary outcomes of this study were 5-year postoperative mortality, morbidity, and length of hospital stay following LT. Results: 60,554 (96%) recipients were first LT recipients and 2524 (4%) were ReLT recipients. Compared with first LT, ReLT recipients had significantly higher rates of mortality (OR 1.93, 95%CI 1.76–2.12), overall morbidity (OR 1.80, 95%CI 1.65–1.96), and prolonged length of stay (OR 1.66, 95%CI 1.52–1.81) on multivariate analysis. Morbidity including cardiovascular (CVD) complications (OR 1.32, 95%CI 1.08–1.60), graft failure (OR 2.18, 95%CI 1.84–2.57), infection (OR 2.13, 95%CI 1.82–2.50), and hemorrhage (OR 2.67, 95%CI 2.00–3.61) were significantly greater in ReLT recipients. Compared to first LT, ReLT patients had a significant increase in overall 5-year mortality (p < 0.001), 5-year mortality due to CVD complications (p < 0.001), infection (p = 0.009), but not graft failure (p = 0.3543). Conclusion: ReLT is associated with higher rates of 5-year mortality, overall morbidity, CVD morbidity, infection, and graft failure. Higher 5-year mortality in ReLT is due to CVD and infections. These results could be used in preoperative patient assessment and prognostic counseling for ReLT. Graphical Abstract: [Figure not available: see fulltext.].
AB - Background: Liver transplantation (LT) is life-saving procedure for patients with end-stage liver failure with up to 20% of patients suffering graft failure following primary transplantation. Retransplantation (ReLT) remains the only definitive treatment for irreversible graft failure. Aims: We aimed to explore the postoperative outcomes following liver ReLT. Methods: Patients who had received a liver transplant between 2003 and 2016 were retrospectively identified using the Scientific Registry of Transplant Recipients (SRTRs). Patients were stratified based on previous liver transplant history. The primary outcomes of this study were 5-year postoperative mortality, morbidity, and length of hospital stay following LT. Results: 60,554 (96%) recipients were first LT recipients and 2524 (4%) were ReLT recipients. Compared with first LT, ReLT recipients had significantly higher rates of mortality (OR 1.93, 95%CI 1.76–2.12), overall morbidity (OR 1.80, 95%CI 1.65–1.96), and prolonged length of stay (OR 1.66, 95%CI 1.52–1.81) on multivariate analysis. Morbidity including cardiovascular (CVD) complications (OR 1.32, 95%CI 1.08–1.60), graft failure (OR 2.18, 95%CI 1.84–2.57), infection (OR 2.13, 95%CI 1.82–2.50), and hemorrhage (OR 2.67, 95%CI 2.00–3.61) were significantly greater in ReLT recipients. Compared to first LT, ReLT patients had a significant increase in overall 5-year mortality (p < 0.001), 5-year mortality due to CVD complications (p < 0.001), infection (p = 0.009), but not graft failure (p = 0.3543). Conclusion: ReLT is associated with higher rates of 5-year mortality, overall morbidity, CVD morbidity, infection, and graft failure. Higher 5-year mortality in ReLT is due to CVD and infections. These results could be used in preoperative patient assessment and prognostic counseling for ReLT. Graphical Abstract: [Figure not available: see fulltext.].
KW - Liver retransplant (ReLT)
KW - Liver transplant (LT)
KW - Scientific registry of transplant recipients (SRTR)
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U2 - 10.1007/s10620-023-08065-2
DO - 10.1007/s10620-023-08065-2
M3 - Article
C2 - 37597085
AN - SCOPUS:85168371679
SN - 0163-2116
VL - 68
SP - 4039
EP - 4049
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 10
ER -