TY - JOUR
T1 - Mood Disorders
T2 - The Gut Bacteriome and Beyond
AU - McGuinness, Amelia J.
AU - Loughman, Amy
AU - Foster, Jane A.
AU - Jacka, Felice
N1 - Publisher Copyright:
© 2023 Society of Biological Psychiatry
PY - 2024/2/15
Y1 - 2024/2/15
N2 - Knowledge of the microbiome-gut-brain axis has revolutionized the field of psychiatry. It is now well recognized that the gut bacteriome is associated with, and likely influences, the pathogenesis of mental disorders, including major depressive disorder and bipolar disorder. However, while substantial advances in the field of microbiome science have been made, we have likely only scratched the surface in our understanding of how these ecosystems might contribute to mental disorder pathophysiology. Beyond the gut bacteriome, research into lesser explored components of the gut microbiome, including the gut virome, mycobiome, archaeome, and parasitome, is increasingly suggesting relevance in psychiatry. The contribution of microbiomes beyond the gut, including the oral, lung, and small intestinal microbiomes, to human health and pathology should not be overlooked. Increasing both our awareness and understanding of these less traversed fields of research are critical to improving the therapeutic benefits of treatments targeting the gut microbiome, including fecal microbiome transplantation, postbiotics and biogenics, and dietary intervention. Interdisciplinary collaborations integrating systems biology approaches are required to fully elucidate how these different microbial components and distinct microbial niches interact with each other and their human hosts. Excitingly, we may be at the start of the next microbiome revolution and thus one step closer to informing the field of precision psychiatry to improve outcomes for those living with mental illness.
AB - Knowledge of the microbiome-gut-brain axis has revolutionized the field of psychiatry. It is now well recognized that the gut bacteriome is associated with, and likely influences, the pathogenesis of mental disorders, including major depressive disorder and bipolar disorder. However, while substantial advances in the field of microbiome science have been made, we have likely only scratched the surface in our understanding of how these ecosystems might contribute to mental disorder pathophysiology. Beyond the gut bacteriome, research into lesser explored components of the gut microbiome, including the gut virome, mycobiome, archaeome, and parasitome, is increasingly suggesting relevance in psychiatry. The contribution of microbiomes beyond the gut, including the oral, lung, and small intestinal microbiomes, to human health and pathology should not be overlooked. Increasing both our awareness and understanding of these less traversed fields of research are critical to improving the therapeutic benefits of treatments targeting the gut microbiome, including fecal microbiome transplantation, postbiotics and biogenics, and dietary intervention. Interdisciplinary collaborations integrating systems biology approaches are required to fully elucidate how these different microbial components and distinct microbial niches interact with each other and their human hosts. Excitingly, we may be at the start of the next microbiome revolution and thus one step closer to informing the field of precision psychiatry to improve outcomes for those living with mental illness.
KW - Bipolar disorder
KW - Depression
KW - Major depressive disorder
KW - Microbiome
KW - Mood disorders
UR - http://www.scopus.com/inward/record.url?scp=85178179041&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85178179041&partnerID=8YFLogxK
U2 - 10.1016/j.biopsych.2023.08.020
DO - 10.1016/j.biopsych.2023.08.020
M3 - Review article
C2 - 37661007
AN - SCOPUS:85178179041
SN - 0006-3223
VL - 95
SP - 319
EP - 328
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 4
ER -