TY - GEN
T1 - Monitoring tumor growth and treatment in small animals with magnetic resonance and optical tomographic imaging
AU - Masciotti, J.
AU - Provenzano, F.
AU - Papa, J.
AU - Klose, A.
AU - Hur, J.
AU - Gu, X.
AU - Yamashiro, D.
AU - Kandel, J.
AU - Hielscher, A. H.
PY - 2006
Y1 - 2006
N2 - Small animal models are employed to simulate disease in humans and to study its progression, what factors are important to the disease process, and to study the disease treatment. Biomedical imaging modalities such as magnetic resonance imaging (MRI) and Optical Tomography make it possible to non-invasively monitor the progression of diseases in living small animals and study the efficacy of drugs and treatment protocols. MRI is an established imaging modality capable of obtaining high resolution anatomical images and along with contrast agents allow the studying of blood volume. Optical tomography, on the other hand, is an emerging imaging modality, which, while much lower in spatial resolution, can separate the effects of oxyhemoglobin, deoxyhemoglobin, and blood volume with high temporal resolution. In this study we apply these modalities to imaging the growth of kidney tumors and then there treatment by an anti-VEGF agent. We illustrate how these imaging modalities have their individual uses, but can still supplement each other and cross validation can be performed.
AB - Small animal models are employed to simulate disease in humans and to study its progression, what factors are important to the disease process, and to study the disease treatment. Biomedical imaging modalities such as magnetic resonance imaging (MRI) and Optical Tomography make it possible to non-invasively monitor the progression of diseases in living small animals and study the efficacy of drugs and treatment protocols. MRI is an established imaging modality capable of obtaining high resolution anatomical images and along with contrast agents allow the studying of blood volume. Optical tomography, on the other hand, is an emerging imaging modality, which, while much lower in spatial resolution, can separate the effects of oxyhemoglobin, deoxyhemoglobin, and blood volume with high temporal resolution. In this study we apply these modalities to imaging the growth of kidney tumors and then there treatment by an anti-VEGF agent. We illustrate how these imaging modalities have their individual uses, but can still supplement each other and cross validation can be performed.
KW - MRI
KW - Multimodality Imaging
KW - Optical Tomography
KW - Small animal imaging
KW - VEGF
UR - http://www.scopus.com/inward/record.url?scp=33646369659&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646369659&partnerID=8YFLogxK
U2 - 10.1117/12.647138
DO - 10.1117/12.647138
M3 - Conference contribution
AN - SCOPUS:33646369659
SN - 0819461237
SN - 9780819461230
T3 - Proceedings of SPIE - The International Society for Optical Engineering
BT - Proceedings of SPIE - The International Society for Optical Engineering
T2 - Multimodal Biomedical Imaging
Y2 - 21 January 2006 through 24 January 2006
ER -