Monitoring physiological function by detection of exogenous fluorescent contrast agents

Richard B. Dorshow; Joseph E. Bugaj; Samuel Achilefu; Raghavan Rajagopalan; Arthur H. Combs

Monitoring physiological function by detection of exogenous fluorescent contrast agents

Richard B. Dorshow, Joseph E. Bugaj, Samuel Achilefu, Raghavan Rajagopalan, Arthur H. Combs

Research output: Contribution to journal › Conference article › peer-review

Abstract

An invasive in vivo fluorescence detection scheme was employed to continuously monitor exogenous dye clearance from the vasculature. This invasive physiological monitoring technique was successfully demonstrated in a rabbit model. A commercially available catheter with embedded fiber optics was employed to transmit the excitation light and detect the emitted fluorescence. The clearance of indocyanine green, known to be exclusively cleared from the blood stream by the liver, was determined invasively. The clearance curves determined by this novel invasive method replicated the clearance curves in the same animals employing the non-invasive method established previously. Thus, the feasibility of a new invasive method for physiological function assessment was established.

Original language	English (US)
Pages (from-to)	2-8
Number of pages	7
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	3599
State	Published - 1999
Externally published	Yes
Event	Proceedings of the 1999 Optical Diagnostics of Biological Fluids IV - San Jose, CA, USA Duration: Jan 26 1999 → Jan 27 1999

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

Cite this

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title = "Monitoring physiological function by detection of exogenous fluorescent contrast agents",

abstract = "An invasive in vivo fluorescence detection scheme was employed to continuously monitor exogenous dye clearance from the vasculature. This invasive physiological monitoring technique was successfully demonstrated in a rabbit model. A commercially available catheter with embedded fiber optics was employed to transmit the excitation light and detect the emitted fluorescence. The clearance of indocyanine green, known to be exclusively cleared from the blood stream by the liver, was determined invasively. The clearance curves determined by this novel invasive method replicated the clearance curves in the same animals employing the non-invasive method established previously. Thus, the feasibility of a new invasive method for physiological function assessment was established.",

author = "Dorshow, {Richard B.} and Bugaj, {Joseph E.} and Samuel Achilefu and Raghavan Rajagopalan and Combs, {Arthur H.}",

year = "1999",

language = "English (US)",

volume = "3599",

pages = "2--8",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

issn = "0277-786X",

publisher = "SPIE",

note = "Proceedings of the 1999 Optical Diagnostics of Biological Fluids IV ; Conference date: 26-01-1999 Through 27-01-1999",

}

TY - JOUR

T1 - Monitoring physiological function by detection of exogenous fluorescent contrast agents

AU - Dorshow, Richard B.

AU - Bugaj, Joseph E.

AU - Achilefu, Samuel

AU - Rajagopalan, Raghavan

AU - Combs, Arthur H.

PY - 1999

Y1 - 1999

N2 - An invasive in vivo fluorescence detection scheme was employed to continuously monitor exogenous dye clearance from the vasculature. This invasive physiological monitoring technique was successfully demonstrated in a rabbit model. A commercially available catheter with embedded fiber optics was employed to transmit the excitation light and detect the emitted fluorescence. The clearance of indocyanine green, known to be exclusively cleared from the blood stream by the liver, was determined invasively. The clearance curves determined by this novel invasive method replicated the clearance curves in the same animals employing the non-invasive method established previously. Thus, the feasibility of a new invasive method for physiological function assessment was established.

AB - An invasive in vivo fluorescence detection scheme was employed to continuously monitor exogenous dye clearance from the vasculature. This invasive physiological monitoring technique was successfully demonstrated in a rabbit model. A commercially available catheter with embedded fiber optics was employed to transmit the excitation light and detect the emitted fluorescence. The clearance of indocyanine green, known to be exclusively cleared from the blood stream by the liver, was determined invasively. The clearance curves determined by this novel invasive method replicated the clearance curves in the same animals employing the non-invasive method established previously. Thus, the feasibility of a new invasive method for physiological function assessment was established.

UR - http://www.scopus.com/inward/record.url?scp=0032673811&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032673811&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:0032673811

SN - 0277-786X

VL - 3599

SP - 2

EP - 8

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

T2 - Proceedings of the 1999 Optical Diagnostics of Biological Fluids IV

Y2 - 26 January 1999 through 27 January 1999

ER -

Monitoring physiological function by detection of exogenous fluorescent contrast agents

Abstract

ASJC Scopus subject areas

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