Molecular prognostic and predictive factors in cervical cancer

Jayanthi S Lea, Carolyn Y. Muller

Research output: Chapter in Book/Report/Conference proceedingChapter


Biomarker studies in preinvasive cervical disease and transition to invasive cancer are geared to understanding the biologic consequence of HPV infection in relation to clinically relevant cervical disease. There are two critical endpoints on the spectrum of cervical dysplasia. (Figure 18.2). The initial point (A) represents the cell at risk due to active HPV infection, whereas the second point (B) represents the clinically relevant preinvasive lesion, cervical intraepithelial neoplasia (CIN) 3 or carcinoma in situ (CIS).The latter lesion is the immediate precursor to invasive cervical cancer (C), and is the target for molecular diagnostic strategies, chemoprevention targeted at reversing aberrant molecular pathways in the preinvasive cells and vaccine strategies aimed at preventing the initiation step.The following sections will highlight some of the progress made in this translational science.

Original languageEnglish (US)
Title of host publicationPrognostic and Predictive Factors in Gynecologic Cancers
PublisherCRC Press
Number of pages12
ISBN (Electronic)9780203089781
ISBN (Print)9780415391726
StatePublished - Jan 1 2007

ASJC Scopus subject areas

  • General Medicine


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