TY - JOUR
T1 - Molecular modeling of substituted polysaccharides
AU - Chandrasekaran, R.
AU - Radha, A.
AU - Giacometti, A.
N1 - Funding Information:
This work was supported in part by the Industrial Consortium of the Whistler Center for Carbohydrate Research;K elco, Division of Merck; Rhone-Poulenc Specialty Chemical Company; Fidia Advanced BiopolymersI,t aly; and theN ational ScienceF oundation (MCB-9219736)A. .G. acknowledgeas fellowshipf rom the Italian Ministry for Universitiesa nd Scientifica nd TechnologicaRl esearch(M URST, Rome, Italy).
PY - 1995
Y1 - 1995
N2 - X-ray diffraction patterns of gellan, high acyl native gellan and branched polymer welan correspond to polycrystalline and well oriented specimens. Their molecular structures are strikingly similar, but their packing arrangements are not. The benzyl ester of gellan diffracts like gellan implying that a gellan-like double helix can sustain this substitution. Likewise, the benzyl ester of hyaluronan can adopt any of the reported single- and double-helical forms of hyaluronan itself. Carboxymethylhydroxypropyl guaran (CMHPG) diffracts similarly to guaran. The hydroxypropyl and carboxymethyl groups can cause favorable association of a pair of CMHPG chains which can further be stabilized by divalent cations, one for two carboxymethyl groups belonging to different chains. X-ray data combined with modeling calculations have revealed the details of the molecular architectures in each case to varying extents.
AB - X-ray diffraction patterns of gellan, high acyl native gellan and branched polymer welan correspond to polycrystalline and well oriented specimens. Their molecular structures are strikingly similar, but their packing arrangements are not. The benzyl ester of gellan diffracts like gellan implying that a gellan-like double helix can sustain this substitution. Likewise, the benzyl ester of hyaluronan can adopt any of the reported single- and double-helical forms of hyaluronan itself. Carboxymethylhydroxypropyl guaran (CMHPG) diffracts similarly to guaran. The hydroxypropyl and carboxymethyl groups can cause favorable association of a pair of CMHPG chains which can further be stabilized by divalent cations, one for two carboxymethyl groups belonging to different chains. X-ray data combined with modeling calculations have revealed the details of the molecular architectures in each case to varying extents.
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U2 - 10.1016/0144-8617(95)00078-X
DO - 10.1016/0144-8617(95)00078-X
M3 - Article
AN - SCOPUS:0343300029
SN - 0144-8617
VL - 28
SP - 49
EP - 59
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
IS - 1
ER -