TY - JOUR
T1 - Molecular mediators of hepatic steatosis and liver injury
AU - Browning, Jeffrey D.
AU - Horton, Jay D.
PY - 2004/7
Y1 - 2004/7
N2 - Obesity and its associated comorbidities are among the most prevalent and challenging conditions confronting the medical profession in the 21st century. A major metabolic consequence of obesity is insulin resistance, which is strongly associated with the deposition of triglycerides; in the liver. Hepatic steatosis can either be a benign, noninflammatory condition that appears to have no adverse sequelae or can be associated with steatohepatitis: a condition that can result in end-stage liver disease, accounting for up to 14% of liver transplants in the US. Here we highlight recent advances in our understanding of the molecular events contributing to hepatic steatosis and nonalcoholic steatohepatitis.
AB - Obesity and its associated comorbidities are among the most prevalent and challenging conditions confronting the medical profession in the 21st century. A major metabolic consequence of obesity is insulin resistance, which is strongly associated with the deposition of triglycerides; in the liver. Hepatic steatosis can either be a benign, noninflammatory condition that appears to have no adverse sequelae or can be associated with steatohepatitis: a condition that can result in end-stage liver disease, accounting for up to 14% of liver transplants in the US. Here we highlight recent advances in our understanding of the molecular events contributing to hepatic steatosis and nonalcoholic steatohepatitis.
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U2 - 10.1172/JCI200422422
DO - 10.1172/JCI200422422
M3 - Review article
C2 - 15254578
AN - SCOPUS:4043077961
SN - 0021-9738
VL - 114
SP - 147
EP - 152
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 2
ER -