TY - JOUR
T1 - Molecular Mechanisms Underlying Accelerated Aging by Defects in the FGF23-Klotho System
AU - Kuro-O, Makoto
N1 - Funding Information:
This article is supported in part by Japan Society for the Promotion of Science (Grant nos. 16H05302, 16K15470) and AMED-CREST, Japan Agency for Medical Research and Development.
Publisher Copyright:
© 2018 Makoto Kuro-o.
PY - 2018
Y1 - 2018
N2 - The basic research of aging has been primarily focused on elucidating mechanisms of aging and longevity that are evolutionarily conserved from yeasts to primates. Such efforts have culminated in the notion that (1) senescence at the cellular level is associated with aging at the organismal level and that (2) calorie restriction and growth suppression decelerate aging. However, these important findings in the basic research have not necessarily been linked to improvement of daily medical practice in the aging society. It has become increasingly important to investigate mechanisms of aging unique to mammals or humans and apply the research fruits for the treatment of major age-related disorders to extend the health span. Seminal studies on the klotho mouse, a mutant exhibiting a premature aging syndrome, have identified phosphate as a proaging factor in mammals. In this review, mechanisms of phosphate-induced premature aging and potential therapeutic targets will be discussed, which may be directly applicable for developing novel strategies for the treatment of chronic kidney disease and its complications.
AB - The basic research of aging has been primarily focused on elucidating mechanisms of aging and longevity that are evolutionarily conserved from yeasts to primates. Such efforts have culminated in the notion that (1) senescence at the cellular level is associated with aging at the organismal level and that (2) calorie restriction and growth suppression decelerate aging. However, these important findings in the basic research have not necessarily been linked to improvement of daily medical practice in the aging society. It has become increasingly important to investigate mechanisms of aging unique to mammals or humans and apply the research fruits for the treatment of major age-related disorders to extend the health span. Seminal studies on the klotho mouse, a mutant exhibiting a premature aging syndrome, have identified phosphate as a proaging factor in mammals. In this review, mechanisms of phosphate-induced premature aging and potential therapeutic targets will be discussed, which may be directly applicable for developing novel strategies for the treatment of chronic kidney disease and its complications.
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U2 - 10.1155/2018/9679841
DO - 10.1155/2018/9679841
M3 - Review article
C2 - 29951315
AN - SCOPUS:85048154109
SN - 2090-214X
VL - 2018
JO - International Journal of Nephrology
JF - International Journal of Nephrology
M1 - 9679841
ER -