Molecular mechanism of the Neurospora circadian oscillator

Guo Jinhu, Liu Yi

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Circadian clocks are the internal time-keeping mechanisms for organisms to synchronize their cellular and physiological processes to the daily light/dark cycles. The molecular mechanisms underlying circadian clocks are remarkably similar in eukaryotes. Neurospora crassa, a filamentous fungus, is one of the best understood model organisms for circadian research. In recent years, accumulating data have revealed complex regulation in the Neurospora circadian clock at transcriptional, posttranscriptional, post-translational and epigenetic levels. Here we review the recent progress towards our understanding of the molecular mechanism of the Neurospora circadian oscillator. These advances have provided novel insights and furthered our understanding of the mechanism of eukaryotic circadian clocks.

Original languageEnglish (US)
Pages (from-to)331-341
Number of pages11
JournalProtein and Cell
Issue number4
StatePublished - Apr 2010


  • Neurospora crassa
  • circadian clock
  • circadian oscillator
  • eukaryotes

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Drug Discovery
  • Cell Biology


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