Molecular imaging of lymphoid organs and immune activation by positron emission tomography with a new [18F]-labeled 2′-deoxycytidine analog

Caius G. Radu; Chengyi J. Shu; Evan Nair-Gill; Stephanie M. Shelly; Jorge R. Barrio; Nagichettiar Satyamurthy; Michael E. Phelps; Owen N. Witte

doi:10.1038/nm1724

Molecular imaging of lymphoid organs and immune activation by positron emission tomography with a new [¹⁸F]-labeled 2′-deoxycytidine analog

Caius G. Radu, Chengyi J. Shu, Evan Nair-Gill, Stephanie M. Shelly, Jorge R. Barrio, Nagichettiar Satyamurthy, Michael E. Phelps, Owen N. Witte

Research output: Contribution to journal › Article › peer-review

177 Scopus citations

Abstract

Monitoring immune function with molecular imaging could have a considerable impact on the diagnosis and treatment evaluation of immunological disorders and therapeutic immune responses. Positron emission tomography (PET) is a molecular imaging modality with applications in cancer and other diseases. PET studies of immune function have been limited by a lack of specialized probes. We identified [¹⁸F]FAC (1-(2′-deoxy-2′-[¹⁸F] fluoroarabinofuranosyl) cytosine) by differential screening as a new PET probe for the deoxyribonucleotide salvage pathway. [¹⁸F]FAC enabled visualization of lymphoid organs and was sensitive to localized immune activation in a mouse model of antitumor immunity. [¹⁸F]FAC microPET also detected early changes in lymphoid mass in systemic autoimmunity and allowed evaluation of immunosuppressive therapy. These data support the use of [¹⁸F]FAC PET for immune monitoring and suggest a wide range of clinical applications in immune disorders and in certain types of cancer.

Original language	English (US)
Pages (from-to)	783-788
Number of pages	6
Journal	Nature medicine
Volume	14
Issue number	7
DOIs	https://doi.org/10.1038/nm1724
State	Published - Jul 2008
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1038/nm1724

Cite this

@article{eba1b12000f4467985d01165c3fa4906,

title = "Molecular imaging of lymphoid organs and immune activation by positron emission tomography with a new [18F]-labeled 2′-deoxycytidine analog",

abstract = "Monitoring immune function with molecular imaging could have a considerable impact on the diagnosis and treatment evaluation of immunological disorders and therapeutic immune responses. Positron emission tomography (PET) is a molecular imaging modality with applications in cancer and other diseases. PET studies of immune function have been limited by a lack of specialized probes. We identified [18F]FAC (1-(2′-deoxy-2′-[18F] fluoroarabinofuranosyl) cytosine) by differential screening as a new PET probe for the deoxyribonucleotide salvage pathway. [18F]FAC enabled visualization of lymphoid organs and was sensitive to localized immune activation in a mouse model of antitumor immunity. [18F]FAC microPET also detected early changes in lymphoid mass in systemic autoimmunity and allowed evaluation of immunosuppressive therapy. These data support the use of [18F]FAC PET for immune monitoring and suggest a wide range of clinical applications in immune disorders and in certain types of cancer.",

author = "Radu, {Caius G.} and Shu, {Chengyi J.} and Evan Nair-Gill and Shelly, {Stephanie M.} and Barrio, {Jorge R.} and Nagichettiar Satyamurthy and Phelps, {Michael E.} and Witte, {Owen N.}",

year = "2008",

month = jul,

doi = "10.1038/nm1724",

language = "English (US)",

volume = "14",

pages = "783--788",

journal = "Nature medicine",

issn = "1078-8956",

publisher = "Nature Publishing Group",

number = "7",

}

TY - JOUR

T1 - Molecular imaging of lymphoid organs and immune activation by positron emission tomography with a new [18F]-labeled 2′-deoxycytidine analog

AU - Radu, Caius G.

AU - Shu, Chengyi J.

AU - Nair-Gill, Evan

AU - Shelly, Stephanie M.

AU - Barrio, Jorge R.

AU - Satyamurthy, Nagichettiar

AU - Phelps, Michael E.

AU - Witte, Owen N.

PY - 2008/7

Y1 - 2008/7

N2 - Monitoring immune function with molecular imaging could have a considerable impact on the diagnosis and treatment evaluation of immunological disorders and therapeutic immune responses. Positron emission tomography (PET) is a molecular imaging modality with applications in cancer and other diseases. PET studies of immune function have been limited by a lack of specialized probes. We identified [18F]FAC (1-(2′-deoxy-2′-[18F] fluoroarabinofuranosyl) cytosine) by differential screening as a new PET probe for the deoxyribonucleotide salvage pathway. [18F]FAC enabled visualization of lymphoid organs and was sensitive to localized immune activation in a mouse model of antitumor immunity. [18F]FAC microPET also detected early changes in lymphoid mass in systemic autoimmunity and allowed evaluation of immunosuppressive therapy. These data support the use of [18F]FAC PET for immune monitoring and suggest a wide range of clinical applications in immune disorders and in certain types of cancer.

AB - Monitoring immune function with molecular imaging could have a considerable impact on the diagnosis and treatment evaluation of immunological disorders and therapeutic immune responses. Positron emission tomography (PET) is a molecular imaging modality with applications in cancer and other diseases. PET studies of immune function have been limited by a lack of specialized probes. We identified [18F]FAC (1-(2′-deoxy-2′-[18F] fluoroarabinofuranosyl) cytosine) by differential screening as a new PET probe for the deoxyribonucleotide salvage pathway. [18F]FAC enabled visualization of lymphoid organs and was sensitive to localized immune activation in a mouse model of antitumor immunity. [18F]FAC microPET also detected early changes in lymphoid mass in systemic autoimmunity and allowed evaluation of immunosuppressive therapy. These data support the use of [18F]FAC PET for immune monitoring and suggest a wide range of clinical applications in immune disorders and in certain types of cancer.

UR - http://www.scopus.com/inward/record.url?scp=46749110051&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=46749110051&partnerID=8YFLogxK

U2 - 10.1038/nm1724

DO - 10.1038/nm1724

M3 - Article

C2 - 18542051

AN - SCOPUS:46749110051

SN - 1078-8956

VL - 14

SP - 783

EP - 788

JO - Nature medicine

JF - Nature medicine

IS - 7

ER -

Molecular imaging of lymphoid organs and immune activation by positron emission tomography with a new [¹⁸F]-labeled 2′-deoxycytidine analog

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this