Molecular Imaging and Precision Medicine in Head and Neck Cancer

Esther Mena; Shwetha Thippsandra; Anusha Yanamadala; Siddaling Redy; Puskar Pattanayak; Rathan M. Subramaniam

doi:10.1016/j.cpet.2016.08.009

Molecular Imaging and Precision Medicine in Head and Neck Cancer

Esther Mena, Shwetha Thippsandra, Anusha Yanamadala, Siddaling Redy, Puskar Pattanayak, Rathan M. Subramaniam

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

The concept of using tumor genomic profiling information has revolutionized personalized cancer treatment. Head and neck (HN) cancer management is being influenced by recent discoveries of activating mutations in epidermal growth factor receptor and related targeted therapies with tyrosine kinase inhibitors, targeted therapies for Kristen Rat Sarcoma, and MET proto-oncogenes. Molecular imaging using PET plays an important role in assessing the biologic behavior of HN cancer with the goal of delivering individualized cancer treatment. This review summarizes recent genomic discoveries in HN cancer and their implications for functional PET imaging in assessing response to targeted therapies, and drug resistance mechanisms.

Original language	English (US)
Pages (from-to)	7-25
Number of pages	19
Journal	PET Clinics
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/j.cpet.2016.08.009
State	Published - Jan 1 2017

Keywords

Head and neck cancer
Molecular imaging
Targeted therapy
Tumor genetic profiling

ASJC Scopus subject areas

Radiation
Radiology Nuclear Medicine and imaging

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10.1016/j.cpet.2016.08.009

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keywords = "Head and neck cancer, Molecular imaging, Targeted therapy, Tumor genetic profiling",

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AU - Mena, Esther

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AU - Yanamadala, Anusha

AU - Redy, Siddaling

AU - Pattanayak, Puskar

AU - Subramaniam, Rathan M.

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AB - The concept of using tumor genomic profiling information has revolutionized personalized cancer treatment. Head and neck (HN) cancer management is being influenced by recent discoveries of activating mutations in epidermal growth factor receptor and related targeted therapies with tyrosine kinase inhibitors, targeted therapies for Kristen Rat Sarcoma, and MET proto-oncogenes. Molecular imaging using PET plays an important role in assessing the biologic behavior of HN cancer with the goal of delivering individualized cancer treatment. This review summarizes recent genomic discoveries in HN cancer and their implications for functional PET imaging in assessing response to targeted therapies, and drug resistance mechanisms.

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KW - Targeted therapy

KW - Tumor genetic profiling

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Molecular Imaging and Precision Medicine in Head and Neck Cancer

Abstract

Keywords

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