Molecular epidemiology of HIV type 2 infections in South India

R. Susmita Gurjar, V. Ravi, Anita Desai

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


A small but significant number of HIV-2 cases have been reported from India. Although all HIV-2 viruses identified belong to subtype A, there are no studies on the diversity of the HIV-2 envelope and other genomic regions from India. Furthermore, HIV-2 envelope quasispecies in infected individuals has not been studied in detail. This study was designed to address these gaps existing in the epidemiology of HIV-2 in the country. Amongst the 4685 HIV-positive samples, 27 (0.57%) were positive for antibodies to HIV-2 by Western blot. Amplification of HIV-2 genomic regions was possible in 10 of these 27 samples. Sequences of the envelope C2V3C3 region (n = 8), partial stretches of LTR (n = 9), and gag-pol (n = 2) were analyzed. Sequences belonged to HIV-2 subtype A clustered together in the phylogenetic tree and were closely related to sequences reported from the neighboring states of Karnataka. The mean quasispecies diversity in a sample was found to be 3.5%.

Original languageEnglish (US)
Pages (from-to)363-372
Number of pages10
JournalAIDS research and human retroviruses
Issue number3
StatePublished - Mar 1 2009
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases


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