TY - JOUR
T1 - Molecular Basis of Hereditary Colorectal Cancer
AU - Hughes, Matthew R.
AU - Huang, Emina H.
N1 - Funding Information:
Supported in part by NIH R01 CA142808 (to EHH).
PY - 2011/6
Y1 - 2011/6
N2 - Advances in molecular biology have defined the molecular basis for colorectal cancer (CRC). Although only a fraction of CRC has been determined to have a hereditary component, the discovery of genetic alterations in these clinical syndromes has permitted definition of similar discoveries in sporadic CRC. Here we delineate the molecular basis for the most common of these defined syndromes, including familial adenomatous polyposis, hereditary nonpolyposis colon cancer, MUTYH-associated polyposis, juvenile polyposis, Peutz-Jeghers syndrome, and Cowden's syndrome. The newest paradigm with implications for the pathogenesis of sporadic CRC is called the cancer stem cell hypothesis. As this paradigm also implicates aberrations in molecular pathways, a brief discussion of this hypothesis is included.
AB - Advances in molecular biology have defined the molecular basis for colorectal cancer (CRC). Although only a fraction of CRC has been determined to have a hereditary component, the discovery of genetic alterations in these clinical syndromes has permitted definition of similar discoveries in sporadic CRC. Here we delineate the molecular basis for the most common of these defined syndromes, including familial adenomatous polyposis, hereditary nonpolyposis colon cancer, MUTYH-associated polyposis, juvenile polyposis, Peutz-Jeghers syndrome, and Cowden's syndrome. The newest paradigm with implications for the pathogenesis of sporadic CRC is called the cancer stem cell hypothesis. As this paradigm also implicates aberrations in molecular pathways, a brief discussion of this hypothesis is included.
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U2 - 10.1053/j.scrs.2010.12.002
DO - 10.1053/j.scrs.2010.12.002
M3 - Article
C2 - 21779143
AN - SCOPUS:79956161086
SN - 1043-1489
VL - 22
SP - 65
EP - 70
JO - Seminars in Colon and Rectal Surgery
JF - Seminars in Colon and Rectal Surgery
IS - 2
ER -