MOG Antibody-Associated Disease and Thymic Hyperplasia: From the National Multiple Sclerosis Society Case Conference Proceedings

Brigitte Hurtubise; Elliot M. Frohman; Steven Galetta; Laura J. Balcer; Teresa C. Frohman; Robert P. Lisak; Scott D. Newsome; Jennifer S. Graves; Scott S. Zamvil; Lilyana Amezcua

doi:10.1212/NXI.0000000000200077

MOG Antibody-Associated Disease and Thymic Hyperplasia: From the National Multiple Sclerosis Society Case Conference Proceedings

Brigitte Hurtubise, Elliot M. Frohman, Steven Galetta, Laura J. Balcer, Teresa C. Frohman, Robert P. Lisak, Scott D. Newsome, Jennifer S. Graves, Scott S. Zamvil, Lilyana Amezcua

Research output: Contribution to journal › Article › peer-review

Abstract

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently described CNS inflammatory disorder that may manifest with optic neuritis, myelitis, seizures, and/or acute disseminated encephalomyelitis. While MOG-specific antibodies in patients with MOGAD are IgG1, a T-cell-dependent antibody isotype, immunologic mechanisms of this disease are not fully understood. Thymic hyperplasia can be associated with certain autoimmune diseases. In this report we describe a case of MOGAD associated with thymic hyperplasia in a young adult.

Original language	English (US)
Journal	Neurology(R) neuroimmunology & neuroinflammation
Volume	10
Issue number	2
DOIs	https://doi.org/10.1212/NXI.0000000000200077
State	Published - Mar 1 2023

ASJC Scopus subject areas

Medicine(all)

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10.1212/NXI.0000000000200077

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Hurtubise, B., Frohman, E. M., Galetta, S., Balcer, L. J., Frohman, T. C., Lisak, R. P., Newsome, S. D., Graves, J. S., Zamvil, S. S., & Amezcua, L. (2023). MOG Antibody-Associated Disease and Thymic Hyperplasia: From the National Multiple Sclerosis Society Case Conference Proceedings. Neurology(R) neuroimmunology & neuroinflammation, 10(2). https://doi.org/10.1212/NXI.0000000000200077

Hurtubise, B, Frohman, EM, Galetta, S, Balcer, LJ, Frohman, TC, Lisak, RP, Newsome, SD, Graves, JS, Zamvil, SS & Amezcua, L 2023, 'MOG Antibody-Associated Disease and Thymic Hyperplasia: From the National Multiple Sclerosis Society Case Conference Proceedings', Neurology(R) neuroimmunology & neuroinflammation, vol. 10, no. 2. https://doi.org/10.1212/NXI.0000000000200077

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title = "MOG Antibody-Associated Disease and Thymic Hyperplasia: From the National Multiple Sclerosis Society Case Conference Proceedings",

abstract = "Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently described CNS inflammatory disorder that may manifest with optic neuritis, myelitis, seizures, and/or acute disseminated encephalomyelitis. While MOG-specific antibodies in patients with MOGAD are IgG1, a T-cell-dependent antibody isotype, immunologic mechanisms of this disease are not fully understood. Thymic hyperplasia can be associated with certain autoimmune diseases. In this report we describe a case of MOGAD associated with thymic hyperplasia in a young adult.",

author = "Brigitte Hurtubise and Frohman, {Elliot M.} and Steven Galetta and Balcer, {Laura J.} and Frohman, {Teresa C.} and Lisak, {Robert P.} and Newsome, {Scott D.} and Graves, {Jennifer S.} and Zamvil, {Scott S.} and Lilyana Amezcua",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.",

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doi = "10.1212/NXI.0000000000200077",

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T2 - From the National Multiple Sclerosis Society Case Conference Proceedings

AU - Hurtubise, Brigitte

AU - Frohman, Elliot M.

AU - Galetta, Steven

AU - Balcer, Laura J.

AU - Frohman, Teresa C.

AU - Lisak, Robert P.

AU - Newsome, Scott D.

AU - Graves, Jennifer S.

AU - Zamvil, Scott S.

AU - Amezcua, Lilyana

PY - 2023/3/1

Y1 - 2023/3/1

N2 - Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently described CNS inflammatory disorder that may manifest with optic neuritis, myelitis, seizures, and/or acute disseminated encephalomyelitis. While MOG-specific antibodies in patients with MOGAD are IgG1, a T-cell-dependent antibody isotype, immunologic mechanisms of this disease are not fully understood. Thymic hyperplasia can be associated with certain autoimmune diseases. In this report we describe a case of MOGAD associated with thymic hyperplasia in a young adult.

AB - Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently described CNS inflammatory disorder that may manifest with optic neuritis, myelitis, seizures, and/or acute disseminated encephalomyelitis. While MOG-specific antibodies in patients with MOGAD are IgG1, a T-cell-dependent antibody isotype, immunologic mechanisms of this disease are not fully understood. Thymic hyperplasia can be associated with certain autoimmune diseases. In this report we describe a case of MOGAD associated with thymic hyperplasia in a young adult.

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MOG Antibody-Associated Disease and Thymic Hyperplasia: From the National Multiple Sclerosis Society Case Conference Proceedings

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