@article{4e567ab6b52a4b629aecc67211d64840,
title = "Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21",
abstract = "Lung cancer is the leading cause of cancer-related deaths in the world, and non-small-cell lung cancer (NSCLC) accounts for 80% of cases. MicroRNA-21 (miR-21) expression is increased and predicts poor survival in NSCLC. Although miR-21 function has been studied in vitro with cancer cell lines, the role of miR-21 in tumor development in vivo is unknown. We utilize transgenic mice with loss-of-function and gain-of-function miR-21 alleles combined with a model of NSCLC to determine the role of miR-21 in lung cancer. We show that overexpression of miR-21 enhances tumorigenesis and that genetic deletion of miR-21 partially protects against tumor formation. MiR-21 drives tumorigenesis through inhibition of negative regulators of the Ras/MEK/ERK pathway and inhibition of apoptosis.",
author = "Hatley, {Mark E.} and Patrick, {David M.} and Garcia, {Matthew R.} and Richardson, {James A.} and Rhonda Bassel-Duby and {van Rooij}, Eva and Olson, {Eric N.}",
note = "Funding Information: We are grateful to John McAnally for transgenic injection, Jose Cabrera for figure preparation, and Lillian Sutherland and John Shelton for experimental assistance. Work in Eric Olson's laboratory was supported by grants from the National Institutes of Health, the Leducq Foundation, the Robert A. Welch Foundation (grant number 1-0025), and the American Heart Association: Jon Holden DeHaan Foundation. E.V.R. was supported by grants from the American Heart Association. Mark E. Hatley is a Pediatric Scientist Development Program Fellow sponsored by the Eunice Shriver Kennedy National Institute of Child Health and Human Development (NICHD Grant Award K12-HD000850). E.N.O. and E.V.R. hold equity in miRagen Therapeutics, which is developing miRNA-based therapies for muscle disease. ",
year = "2010",
month = sep,
doi = "10.1016/j.ccr.2010.08.013",
language = "English (US)",
volume = "18",
pages = "282--293",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "3",
}