Modulation of calcium and potassium currents by lamotrigine

Heinz Grunze, Jörg Von Wegerer, Robert W. Greene, Jörg Walden

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Actions of the new antiepileptic drug lamotrigine (LTG) were characterized using extracellular and whole cell patch clamp recordings from rat CA1 and CA3 pyramidal cells in vitro. The results suggest that LTG, beside its previously described effect on the fast sodium inward current, also modulates - presumably voltage-gated - calcium currents and the transient potassium outward current I(D). These may be effective mechanisms to inhibit pathological excitation in epilepsy and may be of potential benefit in treating underlying cellular disturbances in bipolar disorder.

Original languageEnglish (US)
Pages (from-to)131-138
Number of pages8
Issue number3
StatePublished - Oct 1998


  • Bipolar disorder
  • Calcium
  • Carbamazepine
  • Epilepsy
  • Lamotrigine
  • Potassium
  • Valproate
  • Verapamil

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Biological Psychiatry


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