TY - JOUR
T1 - Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for Alzheimer's disease
T2 - a pilot study
AU - Neth, Bryan J.
AU - Mintz, Akiva
AU - Whitlow, Christopher
AU - Jung, Youngkyoo
AU - Solingapuram Sai, Kiran
AU - Register, Thomas C.
AU - Kellar, Derek
AU - Lockhart, Samuel N.
AU - Hoscheidt, Siobhan
AU - Maldjian, Joseph
AU - Heslegrave, Amanda J.
AU - Blennow, Kaj
AU - Cunnane, Stephen C.
AU - Castellano, Christian Alexandre
AU - Zetterberg, Henrik
AU - Craft, Suzanne
N1 - Funding Information:
Supported by the Wake Forest Alzheimer’s Disease Research Center ( P30- AG049638 ), the Hartman Family Foundation, and the Roena B. Kulynych Center for Memory and Cognition Research. The authors thank Dixie Yow; Patricia Wittmer; Deborah Dahl, RN; Timothy Hughes, PhD; and Ben Wagner for technical assistance. The authors would also like to acknowledge the contributions of the Wake Forest Clinical and Translational Science Institute and the laboratory technicians at Sahlgrenska University Hospital, Mölndal, Sweden. The biomarker measurements were supported in part by grants from the Swedish Research Council and Swedish State Support for Clinical Research (ALFGBG).
Funding Information:
Supported by the Wake Forest Alzheimer's Disease Research Center (P30- AG049638), the Hartman Family Foundation, and the Roena B. Kulynych Center for Memory and Cognition Research. The authors thank Dixie Yow; Patricia Wittmer; Deborah Dahl, RN; Timothy Hughes, PhD; and Ben Wagner for technical assistance. The authors would also like to acknowledge the contributions of the Wake Forest Clinical and Translational Science Institute and the laboratory technicians at Sahlgrenska University Hospital, Mölndal, Sweden. The biomarker measurements were supported in part by grants from the Swedish Research Council and Swedish State Support for Clinical Research (ALFGBG).
Publisher Copyright:
© 2019
PY - 2020/2
Y1 - 2020/2
N2 - There is currently no established therapy to treat or prevent Alzheimer's disease. The ketogenic diet supplies an alternative cerebral metabolic fuel, with potential neuroprotective effects. Our goal was to compare the effects of a modified Mediterranean-ketogenic diet (MMKD) and an American Heart Association Diet (AHAD) on cerebrospinal fluid Alzheimer's biomarkers, neuroimaging measures, peripheral metabolism, and cognition in older adults at risk for Alzheimer's. Twenty participants with subjective memory complaints (n = 11) or mild cognitive impairment (n = 9) completed both diets, with 3 participants discontinuing early. Mean compliance rates were 90% for MMKD and 95% for AHAD. All participants had improved metabolic indices following MMKD. MMKD was associated with increased cerebrospinal fluid Aβ42 and decreased tau. There was increased cerebral perfusion and increased cerebral ketone body uptake (11C-acetoacetate PET, in subsample) following MMKD. Memory performance improved after both diets, which may be due to practice effects. Our results suggest that a ketogenic intervention targeted toward adults at risk for Alzheimer's may prove beneficial in the prevention of cognitive decline.
AB - There is currently no established therapy to treat or prevent Alzheimer's disease. The ketogenic diet supplies an alternative cerebral metabolic fuel, with potential neuroprotective effects. Our goal was to compare the effects of a modified Mediterranean-ketogenic diet (MMKD) and an American Heart Association Diet (AHAD) on cerebrospinal fluid Alzheimer's biomarkers, neuroimaging measures, peripheral metabolism, and cognition in older adults at risk for Alzheimer's. Twenty participants with subjective memory complaints (n = 11) or mild cognitive impairment (n = 9) completed both diets, with 3 participants discontinuing early. Mean compliance rates were 90% for MMKD and 95% for AHAD. All participants had improved metabolic indices following MMKD. MMKD was associated with increased cerebrospinal fluid Aβ42 and decreased tau. There was increased cerebral perfusion and increased cerebral ketone body uptake (11C-acetoacetate PET, in subsample) following MMKD. Memory performance improved after both diets, which may be due to practice effects. Our results suggest that a ketogenic intervention targeted toward adults at risk for Alzheimer's may prove beneficial in the prevention of cognitive decline.
KW - Alzheimer's disease
KW - CSF biomarkers
KW - Ketogenic diet
KW - MRI
KW - Mild cognitive impairment
KW - PET
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U2 - 10.1016/j.neurobiolaging.2019.09.015
DO - 10.1016/j.neurobiolaging.2019.09.015
M3 - Article
C2 - 31757576
AN - SCOPUS:85078335869
SN - 0197-4580
VL - 86
SP - 54
EP - 63
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -