TY - JOUR
T1 - Mobilizing diversity
T2 - Transposable element insertions in genetic variation and disease
AU - O'Donnell-Mendell, Kathryn A
AU - Burns, Kathleen H.
N1 - Funding Information:
We thank N Craig and L Dai for their insightful comments. KAO is a fellow of the Damon Runyon Cancer Research Foundation. KHB is supported by a K08 award from the National Cancer Institute and a career award for medical scientists from the Burroughs Wellcome Foundation.
PY - 2010
Y1 - 2010
N2 - Transposable elements (TEs) comprise a large fraction of mammalian genomes. A number of these elements are actively jumping in our genomes today. As a consequence, these insertions provide a source of genetic variation and, in rare cases, these events cause mutations that lead to disease. Yet, the extent to which these elements impact their host genomes is not completely understood. This review will summarize our current understanding of the mechanisms underlying transposon regulation and the contribution of TE insertions to genetic diversity in the germline and in somatic cells. Finally, traditional methods and emerging technologies for identifying transposon insertions will be considered.
AB - Transposable elements (TEs) comprise a large fraction of mammalian genomes. A number of these elements are actively jumping in our genomes today. As a consequence, these insertions provide a source of genetic variation and, in rare cases, these events cause mutations that lead to disease. Yet, the extent to which these elements impact their host genomes is not completely understood. This review will summarize our current understanding of the mechanisms underlying transposon regulation and the contribution of TE insertions to genetic diversity in the germline and in somatic cells. Finally, traditional methods and emerging technologies for identifying transposon insertions will be considered.
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U2 - 10.1186/1759-8753-1-21
DO - 10.1186/1759-8753-1-21
M3 - Review article
C2 - 20813032
AN - SCOPUS:79960636440
SN - 1759-8753
VL - 1
JO - Mobile DNA
JF - Mobile DNA
IS - 1
M1 - 21
ER -