mMTORC1 activation in childhood ependymoma and response to sirolimus

Daniel C. Bowers; Blanka Kucejova; Linda Margraf; Lynn Gargan; James Brugarolas

doi:10.1007/s11060-010-0455-7

mMTORC1 activation in childhood ependymoma and response to sirolimus

Daniel C. Bowers, Blanka Kucejova, Linda Margraf, Lynn Gargan, James Brugarolas

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Recurrent ependymomas are considered rarely responsive to chemotherapy and often have a dismal prognosis after tumor progression. Below is a brief report of a 6 year old child with a multiply progressive ependymoma whose tumor had a near complete response to sirolimus that was durable for 18 months. Immunohistochemistry for phosphorylated S6, which has been reported to be associated with tumor sensitivity to mTORC1 inhibitors, was positive in this patient's tumor.

Original language	English (US)
Pages (from-to)	797-801
Number of pages	5
Journal	Journal of Neuro-Oncology
Volume	103
Issue number	3
DOIs	https://doi.org/10.1007/s11060-010-0455-7
State	Published - Jul 1 2011

Keywords

Ependymoma
Rapamycin
Sirolimus
mTORC1

ASJC Scopus subject areas

Oncology
Neurology
Clinical Neurology
Cancer Research

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10.1007/s11060-010-0455-7

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abstract = "Recurrent ependymomas are considered rarely responsive to chemotherapy and often have a dismal prognosis after tumor progression. Below is a brief report of a 6 year old child with a multiply progressive ependymoma whose tumor had a near complete response to sirolimus that was durable for 18 months. Immunohistochemistry for phosphorylated S6, which has been reported to be associated with tumor sensitivity to mTORC1 inhibitors, was positive in this patient's tumor.",

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AU - Margraf, Linda

AU - Gargan, Lynn

AU - Brugarolas, James

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N2 - Recurrent ependymomas are considered rarely responsive to chemotherapy and often have a dismal prognosis after tumor progression. Below is a brief report of a 6 year old child with a multiply progressive ependymoma whose tumor had a near complete response to sirolimus that was durable for 18 months. Immunohistochemistry for phosphorylated S6, which has been reported to be associated with tumor sensitivity to mTORC1 inhibitors, was positive in this patient's tumor.

AB - Recurrent ependymomas are considered rarely responsive to chemotherapy and often have a dismal prognosis after tumor progression. Below is a brief report of a 6 year old child with a multiply progressive ependymoma whose tumor had a near complete response to sirolimus that was durable for 18 months. Immunohistochemistry for phosphorylated S6, which has been reported to be associated with tumor sensitivity to mTORC1 inhibitors, was positive in this patient's tumor.

KW - Ependymoma

KW - Rapamycin

KW - Sirolimus

KW - mTORC1

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mMTORC1 activation in childhood ependymoma and response to sirolimus

Abstract

Keywords

ASJC Scopus subject areas

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