Abstract
Patients with rheumatoid arthritis were investigated as a possible source of MLC typing cells. Lymphocytes from four patients that were non‐stimulatory for unrelated subjects suffering from the same disease were chosen for a preliminary analysis. Patterns of reactions obtained were interpreted as being due to LS specificities Ra, Rb, Rc, Rd and r. Ra was found to be included in all R types, but r and R appeared to be mutually exclusive. Ra was found also in the normal family JM, where it was inherited in association with a maternal haplotype HL‐A2, W10. In unrelated individuals these antigens did not show association with any particular HL‐A antigens. The methods described may offer a practical approach for further identification and study of MLC determinants.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 571-579 |
| Number of pages | 9 |
| Journal | Tissue Antigens |
| Volume | 4 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 1974 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Biochemistry
- Genetics