Mitoxantrone as a potential therapy for primary progressive multiple sclerosis

Olaf Stüve, Mariko Kita, Daniel Pelletier, Robert J. Fox, Jerome Stone, Donald E. Goodkin, Scott S. Zamvil

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Mitoxantrone (Novantrone®) was the first drug approved in western Europe and North America for treatment of secondary progressive multiple sclerosis (SPMS) and progressive relapsing MS (PRMS). Pharmacological properties of mitoxantrone, its role in SPMS, the study rational and design of an ongoing multi-centre, double blind, randomized, placebo-controlled phase 2 trial will be outlined in this article.

Original languageEnglish (US)
Pages (from-to)S58-S61
JournalMultiple Sclerosis
Issue numberSUPPL. 1
StatePublished - Jun 2004


  • Genetics
  • Immunology
  • Magnetic resonance imaging
  • Multiple sclerosis
  • Pathology
  • Primary progressive
  • Therapies

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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