Mitosis: Short-circuiting spindle checkpoint signaling

Xuelian Luo; Hongtao Yu

doi:10.1016/j.cub.2012.01.018

Mitosis: Short-circuiting spindle checkpoint signaling

Xuelian Luo, Hongtao Yu

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

The spindle checkpoint forms an intricate signaling circuit to sense unattached kinetochores, to inhibit the anaphase-promoting complex/cyclosome (APC/C), and to delay anaphase onset. Using clever genetic experiments in the budding yeast, Lau and Murray define the endpoint of checkpoint signaling and provide key mechanistic insights into checkpoint inhibition of APC/C.

Original language	English (US)
Pages (from-to)	R128-R130
Journal	Current Biology
Volume	22
Issue number	4
DOIs	https://doi.org/10.1016/j.cub.2012.01.018
State	Published - Feb 21 2012

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

Access to Document

10.1016/j.cub.2012.01.018

Cite this

@article{73f8575f88204558a0044244f70c738f,

title = "Mitosis: Short-circuiting spindle checkpoint signaling",

abstract = "The spindle checkpoint forms an intricate signaling circuit to sense unattached kinetochores, to inhibit the anaphase-promoting complex/cyclosome (APC/C), and to delay anaphase onset. Using clever genetic experiments in the budding yeast, Lau and Murray define the endpoint of checkpoint signaling and provide key mechanistic insights into checkpoint inhibition of APC/C.",

author = "Xuelian Luo and Hongtao Yu",

year = "2012",

month = feb,

day = "21",

doi = "10.1016/j.cub.2012.01.018",

language = "English (US)",

volume = "22",

pages = "R128--R130",

journal = "Current Biology",

issn = "0960-9822",

publisher = "Cell Press",

number = "4",

}

TY - JOUR

T1 - Mitosis

T2 - Short-circuiting spindle checkpoint signaling

AU - Luo, Xuelian

AU - Yu, Hongtao

PY - 2012/2/21

Y1 - 2012/2/21

N2 - The spindle checkpoint forms an intricate signaling circuit to sense unattached kinetochores, to inhibit the anaphase-promoting complex/cyclosome (APC/C), and to delay anaphase onset. Using clever genetic experiments in the budding yeast, Lau and Murray define the endpoint of checkpoint signaling and provide key mechanistic insights into checkpoint inhibition of APC/C.

AB - The spindle checkpoint forms an intricate signaling circuit to sense unattached kinetochores, to inhibit the anaphase-promoting complex/cyclosome (APC/C), and to delay anaphase onset. Using clever genetic experiments in the budding yeast, Lau and Murray define the endpoint of checkpoint signaling and provide key mechanistic insights into checkpoint inhibition of APC/C.

UR - http://www.scopus.com/inward/record.url?scp=84857260706&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857260706&partnerID=8YFLogxK

U2 - 10.1016/j.cub.2012.01.018

DO - 10.1016/j.cub.2012.01.018

M3 - Short survey

C2 - 22361149

AN - SCOPUS:84857260706

SN - 0960-9822

VL - 22

SP - R128-R130

JO - Current Biology

JF - Current Biology

IS - 4

ER -

Mitosis: Short-circuiting spindle checkpoint signaling

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this