Mitosis: Short-circuiting spindle checkpoint signaling

Xuelian Luo, Hongtao Yu

Research output: Contribution to journalShort surveypeer-review

4 Scopus citations


The spindle checkpoint forms an intricate signaling circuit to sense unattached kinetochores, to inhibit the anaphase-promoting complex/cyclosome (APC/C), and to delay anaphase onset. Using clever genetic experiments in the budding yeast, Lau and Murray define the endpoint of checkpoint signaling and provide key mechanistic insights into checkpoint inhibition of APC/C.

Original languageEnglish (US)
Pages (from-to)R128-R130
JournalCurrent Biology
Issue number4
StatePublished - Feb 21 2012

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences


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