TY - JOUR
T1 - Mitochondria from the Outside in
T2 - The Relationship Between Inter-Organelle Crosstalk and Mitochondrial Internal Organization
AU - Friedman, Jonathan R.
N1 - Publisher Copyright:
© The Author(s) 2022.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - A fundamental role of membrane-bound organelles is the compartmentalization and organization of cellular processes. Mitochondria perform an immense number of metabolic chemical reactions and to efficiently regulate these, the organelle organizes its inner membrane into distinct morphological domains, including its characteristic cristae membranes. In recent years, a structural feature of increasing apparent importance is the inter-connection between the mitochondrial exterior and other organelles at membrane contact sites (MCSs). Mitochondria form MCSs with almost every other organelle in the cell, including the endoplasmic reticulum, lipid droplets, and lysosomes, to coordinate global cellular metabolism with mitochondrial metabolism. However, these MCSs not only facilitate the transport of metabolites between organelles, but also directly impinge on the physical shape and functional organization inside mitochondria. In this review, we highlight recent advances in our understanding of how physical connections between other organelles and mitochondria both directly and indirectly influence the internal architecture of mitochondria.
AB - A fundamental role of membrane-bound organelles is the compartmentalization and organization of cellular processes. Mitochondria perform an immense number of metabolic chemical reactions and to efficiently regulate these, the organelle organizes its inner membrane into distinct morphological domains, including its characteristic cristae membranes. In recent years, a structural feature of increasing apparent importance is the inter-connection between the mitochondrial exterior and other organelles at membrane contact sites (MCSs). Mitochondria form MCSs with almost every other organelle in the cell, including the endoplasmic reticulum, lipid droplets, and lysosomes, to coordinate global cellular metabolism with mitochondrial metabolism. However, these MCSs not only facilitate the transport of metabolites between organelles, but also directly impinge on the physical shape and functional organization inside mitochondria. In this review, we highlight recent advances in our understanding of how physical connections between other organelles and mitochondria both directly and indirectly influence the internal architecture of mitochondria.
KW - Ca2 +
KW - cristae
KW - endoplasmic reticulum
KW - inner mitochondrial membrane
KW - interorganelle (inter-organelle)
KW - lipid droplet
KW - lysosome
KW - mitochondrion (mitochondria)
KW - phospholipid
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U2 - 10.1177/25152564221133267
DO - 10.1177/25152564221133267
M3 - Review article
C2 - 36329759
AN - SCOPUS:85174666181
SN - 2515-2564
VL - 5
JO - Contact
JF - Contact
ER -