miRiad Roles for the miR-17-92 Cluster in Development and Disease

Joshua T. Mendell

doi:10.1016/j.cell.2008.04.001

miRiad Roles for the miR-17-92 Cluster in Development and Disease

Joshua T. Mendell

Research output: Contribution to journal › Review article › peer-review

978 Scopus citations

Abstract

MicroRNAs (miRNAs) encoded by the miR-17-92 cluster and its paralogs are known to act as oncogenes. Expression of these miRNAs promotes cell proliferation, suppresses apoptosis of cancer cells, and induces tumor angiogenesis. New work reveals essential functions for these miRNAs not only in tumor formation but also during normal development of the heart, lungs, and immune system.

Original language	English (US)
Pages (from-to)	217-222
Number of pages	6
Journal	Cell
Volume	133
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2008.04.001
State	Published - Apr 18 2008

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2008.04.001

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title = "miRiad Roles for the miR-17-92 Cluster in Development and Disease",

abstract = "MicroRNAs (miRNAs) encoded by the miR-17-92 cluster and its paralogs are known to act as oncogenes. Expression of these miRNAs promotes cell proliferation, suppresses apoptosis of cancer cells, and induces tumor angiogenesis. New work reveals essential functions for these miRNAs not only in tumor formation but also during normal development of the heart, lungs, and immune system.",

author = "Mendell, {Joshua T.}",

note = "Funding Information: I thank R. Chivukula, K. O'Donnell, and K. Smith for helpful comments. J.T.M. is a Rita Allen Foundation Scholar and a Leukemia and Lymphoma Society Scholar and is supported by the NIH (R01 CA120185) and the Sol Goldman Pancreatic Cancer Research Center.",

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AU - Mendell, Joshua T.

N1 - Funding Information: I thank R. Chivukula, K. O'Donnell, and K. Smith for helpful comments. J.T.M. is a Rita Allen Foundation Scholar and a Leukemia and Lymphoma Society Scholar and is supported by the NIH (R01 CA120185) and the Sol Goldman Pancreatic Cancer Research Center.

PY - 2008/4/18

Y1 - 2008/4/18

N2 - MicroRNAs (miRNAs) encoded by the miR-17-92 cluster and its paralogs are known to act as oncogenes. Expression of these miRNAs promotes cell proliferation, suppresses apoptosis of cancer cells, and induces tumor angiogenesis. New work reveals essential functions for these miRNAs not only in tumor formation but also during normal development of the heart, lungs, and immune system.

AB - MicroRNAs (miRNAs) encoded by the miR-17-92 cluster and its paralogs are known to act as oncogenes. Expression of these miRNAs promotes cell proliferation, suppresses apoptosis of cancer cells, and induces tumor angiogenesis. New work reveals essential functions for these miRNAs not only in tumor formation but also during normal development of the heart, lungs, and immune system.

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DO - 10.1016/j.cell.2008.04.001

M3 - Review article

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SP - 217

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JO - Cell

JF - Cell

IS - 2

ER -

miRiad Roles for the miR-17-92 Cluster in Development and Disease

Abstract

ASJC Scopus subject areas

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