Minimally Invasive Treatment Options for Hepatic Uveal Melanoma Metastases

Abin Sajan; Samuel Fordyce; Andrew Sideris; Connie Liou; Zeeshan Toor; John Filtes; Venkatesh Krishnasamy; Noor Ahmad; Stephen Reis; Sidney Brejt; Asad Baig; Shaheer Khan; Michael Caplan; David Sperling; Joshua Weintraub

doi:10.3390/diagnostics13111836

Minimally Invasive Treatment Options for Hepatic Uveal Melanoma Metastases

Abin Sajan, Samuel Fordyce, Andrew Sideris, Connie Liou, Zeeshan Toor, John Filtes, Venkatesh Krishnasamy, Noor Ahmad, Stephen Reis, Sidney Brejt, Asad Baig, Shaheer Khan, Michael Caplan, David Sperling, Joshua Weintraub

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Uveal melanoma is one of the most common primary intraocular malignancies that accounts for about 85% of all ocular melanomas. The pathophysiology of uveal melanoma is distinct from cutaneous melanoma and has separate tumor profiles. The management of uveal melanoma is largely dependent on the presence of metastases, which confers a poor prognosis with a one-year survival reaching only 15%. Although a better understanding of tumor biology has led to the development of novel pharmacologic agents, there is increasing demand for minimally invasive management of hepatic uveal melanoma metastases. Multiple studies have already summarized the systemic therapeutic options available for metastatic uveal melanoma. This review covers the current research for the most prevalent locoregional treatment options for metastatic uveal melanoma including percutaneous hepatic perfusion, immunoembolization, chemoembolization, thermal ablation, and radioembolization.

Original language	English (US)
Article number	1836
Journal	Diagnostics
Volume	13
Issue number	11
DOIs	https://doi.org/10.3390/diagnostics13111836
State	Published - Jun 2023
Externally published	Yes

Keywords

interventional radiology
liver metastases
locoregional therapy
uveal melanoma

ASJC Scopus subject areas

Clinical Biochemistry

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10.3390/diagnostics13111836

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title = "Minimally Invasive Treatment Options for Hepatic Uveal Melanoma Metastases",

abstract = "Uveal melanoma is one of the most common primary intraocular malignancies that accounts for about 85% of all ocular melanomas. The pathophysiology of uveal melanoma is distinct from cutaneous melanoma and has separate tumor profiles. The management of uveal melanoma is largely dependent on the presence of metastases, which confers a poor prognosis with a one-year survival reaching only 15%. Although a better understanding of tumor biology has led to the development of novel pharmacologic agents, there is increasing demand for minimally invasive management of hepatic uveal melanoma metastases. Multiple studies have already summarized the systemic therapeutic options available for metastatic uveal melanoma. This review covers the current research for the most prevalent locoregional treatment options for metastatic uveal melanoma including percutaneous hepatic perfusion, immunoembolization, chemoembolization, thermal ablation, and radioembolization.",

keywords = "interventional radiology, liver metastases, locoregional therapy, uveal melanoma",

author = "Abin Sajan and Samuel Fordyce and Andrew Sideris and Connie Liou and Zeeshan Toor and John Filtes and Venkatesh Krishnasamy and Noor Ahmad and Stephen Reis and Sidney Brejt and Asad Baig and Shaheer Khan and Michael Caplan and David Sperling and Joshua Weintraub",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = jun,

doi = "10.3390/diagnostics13111836",

language = "English (US)",

volume = "13",

journal = "Diagnostics",

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T1 - Minimally Invasive Treatment Options for Hepatic Uveal Melanoma Metastases

AU - Sajan, Abin

AU - Fordyce, Samuel

AU - Sideris, Andrew

AU - Liou, Connie

AU - Toor, Zeeshan

AU - Filtes, John

AU - Krishnasamy, Venkatesh

AU - Ahmad, Noor

AU - Reis, Stephen

AU - Brejt, Sidney

AU - Baig, Asad

AU - Khan, Shaheer

AU - Caplan, Michael

AU - Sperling, David

AU - Weintraub, Joshua

PY - 2023/6

Y1 - 2023/6

N2 - Uveal melanoma is one of the most common primary intraocular malignancies that accounts for about 85% of all ocular melanomas. The pathophysiology of uveal melanoma is distinct from cutaneous melanoma and has separate tumor profiles. The management of uveal melanoma is largely dependent on the presence of metastases, which confers a poor prognosis with a one-year survival reaching only 15%. Although a better understanding of tumor biology has led to the development of novel pharmacologic agents, there is increasing demand for minimally invasive management of hepatic uveal melanoma metastases. Multiple studies have already summarized the systemic therapeutic options available for metastatic uveal melanoma. This review covers the current research for the most prevalent locoregional treatment options for metastatic uveal melanoma including percutaneous hepatic perfusion, immunoembolization, chemoembolization, thermal ablation, and radioembolization.

AB - Uveal melanoma is one of the most common primary intraocular malignancies that accounts for about 85% of all ocular melanomas. The pathophysiology of uveal melanoma is distinct from cutaneous melanoma and has separate tumor profiles. The management of uveal melanoma is largely dependent on the presence of metastases, which confers a poor prognosis with a one-year survival reaching only 15%. Although a better understanding of tumor biology has led to the development of novel pharmacologic agents, there is increasing demand for minimally invasive management of hepatic uveal melanoma metastases. Multiple studies have already summarized the systemic therapeutic options available for metastatic uveal melanoma. This review covers the current research for the most prevalent locoregional treatment options for metastatic uveal melanoma including percutaneous hepatic perfusion, immunoembolization, chemoembolization, thermal ablation, and radioembolization.

KW - interventional radiology

KW - liver metastases

KW - locoregional therapy

KW - uveal melanoma

UR - http://www.scopus.com/inward/record.url?scp=85161753755&partnerID=8YFLogxK

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U2 - 10.3390/diagnostics13111836

DO - 10.3390/diagnostics13111836

M3 - Review article

C2 - 37296688

AN - SCOPUS:85161753755

SN - 2075-4418

VL - 13

JO - Diagnostics

JF - Diagnostics

IS - 11

M1 - 1836

ER -

Minimally Invasive Treatment Options for Hepatic Uveal Melanoma Metastases

Abstract

Keywords

ASJC Scopus subject areas

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