TY - JOUR
T1 - Midtrimester amniotic fluid tumor necrosis factor-alpha does not predict small-for-gestational-age infants
AU - Spong, Catherine Y.
AU - Scherer, David M.
AU - Ghidini, Alessandro
AU - Pezzullo, John C.
AU - Salafia, Carolyn M.
AU - Eglinton, Gary S.
PY - 1997
Y1 - 1997
N2 - Problem: To evaluate the independent ability of midtrimester amniotic fluid tumor necrosis factor-alpha (TNF-α) in the prediction of small-for-gestational-age (SGA) infants. Method of study: In this case-control study, patients delivering a SGA infant were matched with controls based on GA at delivery, maternal age, race, and parity. Patients with immune disease, chronic hypertension, diabetes, asthma, congenital hearts disease, multiple gestation, and fetal anomalies were excluded. Amniotic fluid samples were immunoassayed for TNF-α. Potential confounding variables evaluated were maternal serum alpha-fetoprotein level, smoking history, pregnancy induced hypertension, and neonatal gender. Statistical analysis included Fisher's exact test and ANOVA after log transformation with P < 0.05 considered significant. Results: Eighteen patients delivered SGA neonates and were matched with 41 controls. No significant differences were identified in the confounding variables between patients with SGA neonates and controls. Amniotic fluid TNF-α. levels were not significantly different between patients subsequently delivering SGA neonates and controls [median 7.63 (range 0.25-16.1) pg/mL versus 9.39 (0.25-66.9) pg/mL, P = 0.8]. Conclusions: Midtrimester amniotic fluid TNF-α levels are not predictive of SGA neonates when compared with controls matched for gestational age at delivery.
AB - Problem: To evaluate the independent ability of midtrimester amniotic fluid tumor necrosis factor-alpha (TNF-α) in the prediction of small-for-gestational-age (SGA) infants. Method of study: In this case-control study, patients delivering a SGA infant were matched with controls based on GA at delivery, maternal age, race, and parity. Patients with immune disease, chronic hypertension, diabetes, asthma, congenital hearts disease, multiple gestation, and fetal anomalies were excluded. Amniotic fluid samples were immunoassayed for TNF-α. Potential confounding variables evaluated were maternal serum alpha-fetoprotein level, smoking history, pregnancy induced hypertension, and neonatal gender. Statistical analysis included Fisher's exact test and ANOVA after log transformation with P < 0.05 considered significant. Results: Eighteen patients delivered SGA neonates and were matched with 41 controls. No significant differences were identified in the confounding variables between patients with SGA neonates and controls. Amniotic fluid TNF-α. levels were not significantly different between patients subsequently delivering SGA neonates and controls [median 7.63 (range 0.25-16.1) pg/mL versus 9.39 (0.25-66.9) pg/mL, P = 0.8]. Conclusions: Midtrimester amniotic fluid TNF-α levels are not predictive of SGA neonates when compared with controls matched for gestational age at delivery.
KW - Amniotic fluid
KW - Small-for-gestational-age
KW - TNF-α
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U2 - 10.1111/j.1600-0897.1997.tb00221.x
DO - 10.1111/j.1600-0897.1997.tb00221.x
M3 - Article
C2 - 9127645
AN - SCOPUS:0030945424
SN - 8755-8920
VL - 37
SP - 236
EP - 239
JO - American Journal of Reproductive Immunology
JF - American Journal of Reproductive Immunology
IS - 3
ER -