MicroRNAs and liver disease

Thomas A. Kerr; Kevin M. Korenblat; Nicholas O. Davidson

doi:10.1016/j.trsl.2011.01.008

MicroRNAs and liver disease

Thomas A. Kerr, Kevin M. Korenblat, Nicholas O. Davidson

Research output: Contribution to journal › Review article › peer-review

96 Scopus citations

Abstract

Posttranscriptional regulation of gene expression is now recognized as an important contributor to disease pathogenesis, whose mechanisms include alterations in the function of stability and translational elements within both coding and noncoding regions of messenger RNA. A major component in this regulatory paradigm is the binding both to RNA stability as well as to translational control elements by microRNAs (miRNAs). miRNAs are noncoding endogenously transcribed RNAs that undergo a well-characterized series of processing steps that generate short single-stranded (∼20-22) RNA fragments that bind to complementary regions within a range of targets and in turn lead to mRNA degradation or attenuated translation as a result of trafficking to processing bodies. This article will highlight selected advances in the role of miRNAs in liver disease including nonalcoholic fatty liver disease, viral hepatitis, and hepatocellular carcinoma and will briefly discuss the utility of miRNAs as biomarkers of liver injury and neoplasia.

Original language	English (US)
Pages (from-to)	241-252
Number of pages	12
Journal	Translational Research
Volume	157
Issue number	4
DOIs	https://doi.org/10.1016/j.trsl.2011.01.008
State	Published - Apr 2011

Keywords

3-hydroxy-3-methyl-glutaryl-CoA
A disintegrin and metalloprotease 17
ADAM17
ALT
ASO
FAS
HCC
HCV
HMG-CoA
HO-1
IRES
LNA
MRE
NAFLD
NASH
NCR
PCR
RISC
RNA interference
RNA-induced silencing complex
RNAi
RT-PCR
SNP
SREBP-1c
UTR
aST
alanine aminotransferase
antisense oligonucleotide
aspartate aminotransferase
fatty acid synthase
heme oxygenase-1
hepatitis C virus
hepatocellular carcinoma
internal ribosomal entry site
locked nucleic acid
mTOR
mammalian target of rapamycin
miRNA
miRNA recognition element
microRNA
non-alcoholic steatohepatitis
nonalcoholic fatty liver disease
noncoding region
polymerase chain reaction
reverse-transcription PCR
single nucleotide polymorphism
sterol regulatory element binding protein 1-c
untranslated region

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Biochemistry, medical
Physiology (medical)

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10.1016/j.trsl.2011.01.008

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title = "MicroRNAs and liver disease",

abstract = "Posttranscriptional regulation of gene expression is now recognized as an important contributor to disease pathogenesis, whose mechanisms include alterations in the function of stability and translational elements within both coding and noncoding regions of messenger RNA. A major component in this regulatory paradigm is the binding both to RNA stability as well as to translational control elements by microRNAs (miRNAs). miRNAs are noncoding endogenously transcribed RNAs that undergo a well-characterized series of processing steps that generate short single-stranded (∼20-22) RNA fragments that bind to complementary regions within a range of targets and in turn lead to mRNA degradation or attenuated translation as a result of trafficking to processing bodies. This article will highlight selected advances in the role of miRNAs in liver disease including nonalcoholic fatty liver disease, viral hepatitis, and hepatocellular carcinoma and will briefly discuss the utility of miRNAs as biomarkers of liver injury and neoplasia.",

keywords = "3-hydroxy-3-methyl-glutaryl-CoA, A disintegrin and metalloprotease 17, ADAM17, ALT, ASO, FAS, HCC, HCV, HMG-CoA, HO-1, IRES, LNA, MRE, NAFLD, NASH, NCR, PCR, RISC, RNA interference, RNA-induced silencing complex, RNAi, RT-PCR, SNP, SREBP-1c, UTR, aST, alanine aminotransferase, antisense oligonucleotide, aspartate aminotransferase, fatty acid synthase, heme oxygenase-1, hepatitis C virus, hepatocellular carcinoma, internal ribosomal entry site, locked nucleic acid, mTOR, mammalian target of rapamycin, miRNA, miRNA recognition element, microRNA, non-alcoholic steatohepatitis, nonalcoholic fatty liver disease, noncoding region, polymerase chain reaction, reverse-transcription PCR, single nucleotide polymorphism, sterol regulatory element binding protein 1-c, untranslated region",

author = "Kerr, {Thomas A.} and Korenblat, {Kevin M.} and Davidson, {Nicholas O.}",

note = "Funding Information: Supported by Grants HL-38180, DK-52574, and DK-52560 and by a Fellow to Faculty transition award from the Foundation for Digestive Health and Nutrition . ",

year = "2011",

month = apr,

doi = "10.1016/j.trsl.2011.01.008",

language = "English (US)",

volume = "157",

pages = "241--252",

journal = "Translational Research",

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AU - Kerr, Thomas A.

AU - Korenblat, Kevin M.

AU - Davidson, Nicholas O.

N1 - Funding Information: Supported by Grants HL-38180, DK-52574, and DK-52560 and by a Fellow to Faculty transition award from the Foundation for Digestive Health and Nutrition .

PY - 2011/4

Y1 - 2011/4

N2 - Posttranscriptional regulation of gene expression is now recognized as an important contributor to disease pathogenesis, whose mechanisms include alterations in the function of stability and translational elements within both coding and noncoding regions of messenger RNA. A major component in this regulatory paradigm is the binding both to RNA stability as well as to translational control elements by microRNAs (miRNAs). miRNAs are noncoding endogenously transcribed RNAs that undergo a well-characterized series of processing steps that generate short single-stranded (∼20-22) RNA fragments that bind to complementary regions within a range of targets and in turn lead to mRNA degradation or attenuated translation as a result of trafficking to processing bodies. This article will highlight selected advances in the role of miRNAs in liver disease including nonalcoholic fatty liver disease, viral hepatitis, and hepatocellular carcinoma and will briefly discuss the utility of miRNAs as biomarkers of liver injury and neoplasia.

AB - Posttranscriptional regulation of gene expression is now recognized as an important contributor to disease pathogenesis, whose mechanisms include alterations in the function of stability and translational elements within both coding and noncoding regions of messenger RNA. A major component in this regulatory paradigm is the binding both to RNA stability as well as to translational control elements by microRNAs (miRNAs). miRNAs are noncoding endogenously transcribed RNAs that undergo a well-characterized series of processing steps that generate short single-stranded (∼20-22) RNA fragments that bind to complementary regions within a range of targets and in turn lead to mRNA degradation or attenuated translation as a result of trafficking to processing bodies. This article will highlight selected advances in the role of miRNAs in liver disease including nonalcoholic fatty liver disease, viral hepatitis, and hepatocellular carcinoma and will briefly discuss the utility of miRNAs as biomarkers of liver injury and neoplasia.

KW - 3-hydroxy-3-methyl-glutaryl-CoA

KW - A disintegrin and metalloprotease 17

KW - ADAM17

KW - ALT

KW - ASO

KW - FAS

KW - HCC

KW - HCV

KW - HMG-CoA

KW - HO-1

KW - IRES

KW - LNA

KW - MRE

KW - NAFLD

KW - NASH

KW - NCR

KW - PCR

KW - RISC

KW - RNA interference

KW - RNA-induced silencing complex

KW - RNAi

KW - RT-PCR

KW - SNP

KW - SREBP-1c

KW - UTR

KW - aST

KW - alanine aminotransferase

KW - antisense oligonucleotide

KW - aspartate aminotransferase

KW - fatty acid synthase

KW - heme oxygenase-1

KW - hepatitis C virus

KW - hepatocellular carcinoma

KW - internal ribosomal entry site

KW - locked nucleic acid

KW - mTOR

KW - mammalian target of rapamycin

KW - miRNA

KW - miRNA recognition element

KW - microRNA

KW - non-alcoholic steatohepatitis

KW - nonalcoholic fatty liver disease

KW - noncoding region

KW - polymerase chain reaction

KW - reverse-transcription PCR

KW - single nucleotide polymorphism

KW - sterol regulatory element binding protein 1-c

KW - untranslated region

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UR - http://www.scopus.com/inward/citedby.url?scp=79952792083&partnerID=8YFLogxK

U2 - 10.1016/j.trsl.2011.01.008

DO - 10.1016/j.trsl.2011.01.008

M3 - Review article

C2 - 21420035

AN - SCOPUS:79952792083

SN - 1931-5244

VL - 157

SP - 241

EP - 252

JO - Translational Research

JF - Translational Research

IS - 4

ER -

MicroRNAs and liver disease

Abstract

Keywords

ASJC Scopus subject areas

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