Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effectsin vivo

Michelle D. Combs; Russell H. Knutsen; Thomas J. Broekelmann; Holly M. Toennies; Thomas J. Brett; Chantel A. Miller; Daniel L. Kober; Clarissa S. Craft; Jeffrey J. Atkinson; J. Michael Shipley; Barbara C. Trask; Robert P. Mecham

doi:10.1074/jbc.M113.497727

Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effectsin vivo

Michelle D. Combs, Russell H. Knutsen, Thomas J. Broekelmann, Holly M. Toennies, Thomas J. Brett, Chantel A. Miller, Daniel L. Kober, Clarissa S. Craft, Jeffrey J. Atkinson, J. Michael Shipley, Barbara C. Trask, Robert P. Mecham

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Background:The function of MAGP2 was studied by inactivating its gene (Mfap5^-/-) in mice. Results:Mfap5^-/- mice have a neutrophil deficiency and other phenotypes that are different from MAGP1- and fibrillindeficient animals. Conclusion:MAGP2 has functional roles in hematopoiesis and in vessel wall maintenance. Significance:Characterization of MAGP2 function is crucial to the identification and treatment of microfibril-related disease.

Original language	English (US)
Pages (from-to)	28869-28880
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	40
DOIs	https://doi.org/10.1074/jbc.M113.497727
State	Published - Oct 4 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Combs, M. D., Knutsen, R. H., Broekelmann, T. J., Toennies, H. M., Brett, T. J., Miller, C. A., Kober, D. L., Craft, C. S., Atkinson, J. J., Shipley, J. M., Trask, B. C., & Mecham, R. P. (2013). Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effectsin vivo. Journal of Biological Chemistry, 288(40), 28869-28880. https://doi.org/10.1074/jbc.M113.497727

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title = "Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effectsin vivo",

abstract = "Background:The function of MAGP2 was studied by inactivating its gene (Mfap5-/-) in mice. Results:Mfap5-/- mice have a neutrophil deficiency and other phenotypes that are different from MAGP1- and fibrillindeficient animals. Conclusion:MAGP2 has functional roles in hematopoiesis and in vessel wall maintenance. Significance:Characterization of MAGP2 function is crucial to the identification and treatment of microfibril-related disease.",

author = "Combs, {Michelle D.} and Knutsen, {Russell H.} and Broekelmann, {Thomas J.} and Toennies, {Holly M.} and Brett, {Thomas J.} and Miller, {Chantel A.} and Kober, {Daniel L.} and Craft, {Clarissa S.} and Atkinson, {Jeffrey J.} and Shipley, {J. Michael} and Trask, {Barbara C.} and Mecham, {Robert P.}",

year = "2013",

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doi = "10.1074/jbc.M113.497727",

language = "English (US)",

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T1 - Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effectsin vivo

AU - Combs, Michelle D.

AU - Knutsen, Russell H.

AU - Broekelmann, Thomas J.

AU - Toennies, Holly M.

AU - Brett, Thomas J.

AU - Miller, Chantel A.

AU - Kober, Daniel L.

AU - Craft, Clarissa S.

AU - Atkinson, Jeffrey J.

AU - Shipley, J. Michael

AU - Trask, Barbara C.

AU - Mecham, Robert P.

PY - 2013/10/4

Y1 - 2013/10/4

N2 - Background:The function of MAGP2 was studied by inactivating its gene (Mfap5-/-) in mice. Results:Mfap5-/- mice have a neutrophil deficiency and other phenotypes that are different from MAGP1- and fibrillindeficient animals. Conclusion:MAGP2 has functional roles in hematopoiesis and in vessel wall maintenance. Significance:Characterization of MAGP2 function is crucial to the identification and treatment of microfibril-related disease.

AB - Background:The function of MAGP2 was studied by inactivating its gene (Mfap5-/-) in mice. Results:Mfap5-/- mice have a neutrophil deficiency and other phenotypes that are different from MAGP1- and fibrillindeficient animals. Conclusion:MAGP2 has functional roles in hematopoiesis and in vessel wall maintenance. Significance:Characterization of MAGP2 function is crucial to the identification and treatment of microfibril-related disease.

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Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effectsin vivo

Abstract

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