TY - JOUR
T1 - Microbiota-immune system interactions and enteric virus infection
AU - Woods Acevedo, Mikal A.
AU - Pfeiffer, Julie K.
N1 - Funding Information:
We thank Carolyn Sturge for critical review of the manuscript. Work in J.K.P.’s lab is funded through N.I.H. NIAID grant R01 AI74668 , a Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Diseases Award, and a Faculty Scholar grant from the Howard Hughes Medical Institute . MWA was supported in part by NIH NIAID grant T32 AI007520 .
Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2021/2
Y1 - 2021/2
N2 - Enteric viruses are important human pathogens that pose a significant global health problem. These viruses infect the gastrointestinal tract, which contains a community of microbes called the ‘microbiota’. We and others have shown that intestinal microbiota are crucial for the replication, pathogenesis, and transmission of a variety of enteric viruses. However, the mechanisms underlying microbiota enhancement of enteric virus infection remain unclear. Interestingly, the host immune system is dependent on both the abundance and composition of the intestinal microbiota. Here we review several aspects of how microbiota influence the immune system and how this could potentially impact enteric virus infection.
AB - Enteric viruses are important human pathogens that pose a significant global health problem. These viruses infect the gastrointestinal tract, which contains a community of microbes called the ‘microbiota’. We and others have shown that intestinal microbiota are crucial for the replication, pathogenesis, and transmission of a variety of enteric viruses. However, the mechanisms underlying microbiota enhancement of enteric virus infection remain unclear. Interestingly, the host immune system is dependent on both the abundance and composition of the intestinal microbiota. Here we review several aspects of how microbiota influence the immune system and how this could potentially impact enteric virus infection.
UR - http://www.scopus.com/inward/record.url?scp=85090230911&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85090230911&partnerID=8YFLogxK
U2 - 10.1016/j.coviro.2020.08.005
DO - 10.1016/j.coviro.2020.08.005
M3 - Review article
C2 - 32898729
AN - SCOPUS:85090230911
SN - 1879-6257
VL - 46
SP - 15
EP - 19
JO - Current Opinion in Virology
JF - Current Opinion in Virology
ER -