Micro-SPECT combined with 3-D optical imaging

Edward N. Tsyganov; Pietro P. Antich; Padmakar V. Kulkarni; Ralph P. Mason; Robert W. Parkey; Serguei Y. Seliuonine; Jerry W. Shay; Todd W. Soesbe; Alexander I. Zinchenko

Micro-SPECT combined with 3-D optical imaging

Edward N. Tsyganov, Pietro P. Antich, Padmakar V. Kulkarni, Ralph P. Mason, Robert W. Parkey, Serguei Y. Seliuonine, Jerry W. Shay, Todd W. Soesbe, Alexander I. Zinchenko

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

A resolution enhanced NaI(Tl)-scintillator micro-SPECT device using a pinhole collimator geometry has been built and tested with small animals. This device was constructed based on a depth-of-interaction (DOI) measurement using a thick scintilator crystal and a position sensitive PMT to measure depth dependent scintillator light profiles. DOI measurement eliminates the parallax error that degrades the high spatial resolution required for small animal imaging. This novel technique for 3-D gamma-ray detection was incorporated into a micro-SPECT device and tested with a ⁵⁷Co source and ^98mTc-MDP in mice. We are now investigating the combination of micro-SPECT with 3-D optical imaging, so that the interaction of different biological aspects can be studied by each technique. A simple application permits a 3-D reconstruction of the animal's skin surface thus enhancing visualization and making possible depth-dependent corrections and a quantitative description of biological processes can be achieved. The combination of micro-SPECT and 3-D optical imaging, including bioluminescence 3-D reconstruction, opens new avenues in multi-modality imaging for biology and medicine.

Original language	English (US)
Title of host publication	IEEE Nuclear Science Symposium Conference Record
Editors	J.A. Seibert
Pages	3275-3279
Number of pages	5
Volume	5
State	Published - 2004
Event	2004 Nuclear Science Symposium, Medical Imaging Conference, Symposium on Nuclear Power Systems and the 14th International Workshop on Room Temperature Semiconductor X- and Gamma- Ray Detectors - Rome, Italy Duration: Oct 16 2004 → Oct 22 2004

Other

Other	2004 Nuclear Science Symposium, Medical Imaging Conference, Symposium on Nuclear Power Systems and the 14th International Workshop on Room Temperature Semiconductor X- and Gamma- Ray Detectors
Country/Territory	Italy
City	Rome
Period	10/16/04 → 10/22/04

Keywords

Image Reconstruction
Optical Imaging
Single Photon Emission Computed Tomography
Small Animal Imaging

ASJC Scopus subject areas

Computer Vision and Pattern Recognition
Industrial and Manufacturing Engineering

Cite this

Tsyganov, EN, Antich, PP, Kulkarni, PV, Mason, RP, Parkey, RW, Seliuonine, SY, Shay, JW , Soesbe, TW & Zinchenko, AI 2004, Micro-SPECT combined with 3-D optical imaging. in JA Seibert (ed.), IEEE Nuclear Science Symposium Conference Record. vol. 5, pp. 3275-3279, 2004 Nuclear Science Symposium, Medical Imaging Conference, Symposium on Nuclear Power Systems and the 14th International Workshop on Room Temperature Semiconductor X- and Gamma- Ray Detectors, Rome, Italy, 10/16/04.

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abstract = "A resolution enhanced NaI(Tl)-scintillator micro-SPECT device using a pinhole collimator geometry has been built and tested with small animals. This device was constructed based on a depth-of-interaction (DOI) measurement using a thick scintilator crystal and a position sensitive PMT to measure depth dependent scintillator light profiles. DOI measurement eliminates the parallax error that degrades the high spatial resolution required for small animal imaging. This novel technique for 3-D gamma-ray detection was incorporated into a micro-SPECT device and tested with a 57Co source and 98mTc-MDP in mice. We are now investigating the combination of micro-SPECT with 3-D optical imaging, so that the interaction of different biological aspects can be studied by each technique. A simple application permits a 3-D reconstruction of the animal's skin surface thus enhancing visualization and making possible depth-dependent corrections and a quantitative description of biological processes can be achieved. The combination of micro-SPECT and 3-D optical imaging, including bioluminescence 3-D reconstruction, opens new avenues in multi-modality imaging for biology and medicine.",

keywords = "Image Reconstruction, Optical Imaging, Single Photon Emission Computed Tomography, Small Animal Imaging",

author = "Tsyganov, {Edward N.} and Antich, {Pietro P.} and Kulkarni, {Padmakar V.} and Mason, {Ralph P.} and Parkey, {Robert W.} and Seliuonine, {Serguei Y.} and Shay, {Jerry W.} and Soesbe, {Todd W.} and Zinchenko, {Alexander I.}",

year = "2004",

language = "English (US)",

volume = "5",

pages = "3275--3279",

editor = "J.A. Seibert",

booktitle = "IEEE Nuclear Science Symposium Conference Record",

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AU - Seliuonine, Serguei Y.

AU - Shay, Jerry W.

AU - Soesbe, Todd W.

AU - Zinchenko, Alexander I.

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AB - A resolution enhanced NaI(Tl)-scintillator micro-SPECT device using a pinhole collimator geometry has been built and tested with small animals. This device was constructed based on a depth-of-interaction (DOI) measurement using a thick scintilator crystal and a position sensitive PMT to measure depth dependent scintillator light profiles. DOI measurement eliminates the parallax error that degrades the high spatial resolution required for small animal imaging. This novel technique for 3-D gamma-ray detection was incorporated into a micro-SPECT device and tested with a 57Co source and 98mTc-MDP in mice. We are now investigating the combination of micro-SPECT with 3-D optical imaging, so that the interaction of different biological aspects can be studied by each technique. A simple application permits a 3-D reconstruction of the animal's skin surface thus enhancing visualization and making possible depth-dependent corrections and a quantitative description of biological processes can be achieved. The combination of micro-SPECT and 3-D optical imaging, including bioluminescence 3-D reconstruction, opens new avenues in multi-modality imaging for biology and medicine.

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KW - Optical Imaging

KW - Single Photon Emission Computed Tomography

KW - Small Animal Imaging

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ER -

Micro-SPECT combined with 3-D optical imaging

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Keywords

ASJC Scopus subject areas

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