Metastatic melanoma and matrix metalloproteinases

Gregory Riedlinger, Stephen Kridel, Ali M. Al-Housseini, Jennifer M. Brow, Thomas H. Bugge, Stephen H. Leppla, Nick Duesbery, George Vande Woude, Arthur Frankel

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Metastatic melanoma is a rapidly progressive, incurable malignancy for which novel therapies are needed. Analysis of the biology of melanoma cells reveals a dependency upon several critical pathways, with matrix metalloproteinases (MMPs) essential for tumor spread and dissemination. We describe a growing number of protein therapeutics which target melanoma cells by requiring activation by MMPs. These agents should have distinct side effects and may be useful in combinations with standard-cytotoxic chemotherapy or immunotherapies.

Original languageEnglish (US)
Pages (from-to)897-904
Number of pages8
JournalDrugs of the Future
Issue number9
StatePublished - Sep 2003

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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