Metastatic Atypical and Anaplastic Meningioma: A Case Series and Review of the Literature

Remi A. Kessler; Tomas Garzon-Muvdi; Wuyang Yang; Jon Weingart; Alessandro Olivi; Judy Huang; Henry Brem; Michael Lim

doi:10.1016/j.wneu.2017.01.070

Metastatic Atypical and Anaplastic Meningioma: A Case Series and Review of the Literature

Remi A. Kessler, Tomas Garzon-Muvdi, Wuyang Yang, Jon Weingart, Alessandro Olivi, Judy Huang, Henry Brem, Michael Lim

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Background Atypical (World Health Organization grade II) and anaplastic (World Health Organization grade III) meningiomas are rare, accounting for less than 5% of all meningiomas. Histologic grading has a significant impact on prognosis, risk of recurrence, and the need for adjuvant radiation or chemotherapy. Extracranial metastases are even more infrequent and occur in 0.1% of all cases. Methods Retrospective chart review of 168 patients with diagnosis of WHO grade II and III meningiomas was performed. Six patients with histologically confirmed metastatic disease were identified. Results We discuss the clinical, radiologic, and histopathologic clinical course of 6 patients with metastasis to the lung, liver, and spine from all patients with atypical or anaplastic meningioma treated at Johns Hopkins Hospital from 1993 to 2014. Conclusions We reviewed the literature pertaining to this phenomenon and subsequently assessed the clinical benefits of adjuvant chemotherapeutic agents in patients with meningioma with metastatic disease.

Original language	English (US)
Pages (from-to)	47-56
Number of pages	10
Journal	World Neurosurgery
Volume	101
DOIs	https://doi.org/10.1016/j.wneu.2017.01.070
State	Published - May 1 2017
Externally published	Yes

Keywords

Anaplastic
Atypical
Meningioma
Metastasis
Resection

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1016/j.wneu.2017.01.070

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title = "Metastatic Atypical and Anaplastic Meningioma: A Case Series and Review of the Literature",

abstract = "Background Atypical (World Health Organization grade II) and anaplastic (World Health Organization grade III) meningiomas are rare, accounting for less than 5% of all meningiomas. Histologic grading has a significant impact on prognosis, risk of recurrence, and the need for adjuvant radiation or chemotherapy. Extracranial metastases are even more infrequent and occur in 0.1% of all cases. Methods Retrospective chart review of 168 patients with diagnosis of WHO grade II and III meningiomas was performed. Six patients with histologically confirmed metastatic disease were identified. Results We discuss the clinical, radiologic, and histopathologic clinical course of 6 patients with metastasis to the lung, liver, and spine from all patients with atypical or anaplastic meningioma treated at Johns Hopkins Hospital from 1993 to 2014. Conclusions We reviewed the literature pertaining to this phenomenon and subsequently assessed the clinical benefits of adjuvant chemotherapeutic agents in patients with meningioma with metastatic disease.",

keywords = "Anaplastic, Atypical, Meningioma, Metastasis, Resection",

author = "Kessler, {Remi A.} and Tomas Garzon-Muvdi and Wuyang Yang and Jon Weingart and Alessandro Olivi and Judy Huang and Henry Brem and Michael Lim",

year = "2017",

month = may,

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doi = "10.1016/j.wneu.2017.01.070",

language = "English (US)",

volume = "101",

pages = "47--56",

journal = "World Neurosurgery",

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T1 - Metastatic Atypical and Anaplastic Meningioma

T2 - A Case Series and Review of the Literature

AU - Kessler, Remi A.

AU - Garzon-Muvdi, Tomas

AU - Yang, Wuyang

AU - Weingart, Jon

AU - Olivi, Alessandro

AU - Huang, Judy

AU - Brem, Henry

AU - Lim, Michael

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Background Atypical (World Health Organization grade II) and anaplastic (World Health Organization grade III) meningiomas are rare, accounting for less than 5% of all meningiomas. Histologic grading has a significant impact on prognosis, risk of recurrence, and the need for adjuvant radiation or chemotherapy. Extracranial metastases are even more infrequent and occur in 0.1% of all cases. Methods Retrospective chart review of 168 patients with diagnosis of WHO grade II and III meningiomas was performed. Six patients with histologically confirmed metastatic disease were identified. Results We discuss the clinical, radiologic, and histopathologic clinical course of 6 patients with metastasis to the lung, liver, and spine from all patients with atypical or anaplastic meningioma treated at Johns Hopkins Hospital from 1993 to 2014. Conclusions We reviewed the literature pertaining to this phenomenon and subsequently assessed the clinical benefits of adjuvant chemotherapeutic agents in patients with meningioma with metastatic disease.

AB - Background Atypical (World Health Organization grade II) and anaplastic (World Health Organization grade III) meningiomas are rare, accounting for less than 5% of all meningiomas. Histologic grading has a significant impact on prognosis, risk of recurrence, and the need for adjuvant radiation or chemotherapy. Extracranial metastases are even more infrequent and occur in 0.1% of all cases. Methods Retrospective chart review of 168 patients with diagnosis of WHO grade II and III meningiomas was performed. Six patients with histologically confirmed metastatic disease were identified. Results We discuss the clinical, radiologic, and histopathologic clinical course of 6 patients with metastasis to the lung, liver, and spine from all patients with atypical or anaplastic meningioma treated at Johns Hopkins Hospital from 1993 to 2014. Conclusions We reviewed the literature pertaining to this phenomenon and subsequently assessed the clinical benefits of adjuvant chemotherapeutic agents in patients with meningioma with metastatic disease.

KW - Anaplastic

KW - Atypical

KW - Meningioma

KW - Metastasis

KW - Resection

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Metastatic Atypical and Anaplastic Meningioma: A Case Series and Review of the Literature

Abstract

Keywords

ASJC Scopus subject areas

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