Metal Import through Microbial Membranes

Andrew D. Ferguson, Johann Deisenhofer

Research output: Contribution to journalReview articlepeer-review

110 Scopus citations


Transport systems of Gram-negative bacteria coordinate the passage of metabolites through the outer membrane, periplasm, and the cytoplasmic membrane without compromising the protective properties of the cell envelope. Active transporters orchestrate the import of metals against concentration gradients. These thermodynamically unfavorable processes are coupled to both an electrochemical proton gradient and the hydrolysis of ATP. Crystallographic structures of transport proteins now define in molecular detail most components of an active metal import pathway from Escherichia coli.

Original languageEnglish (US)
Pages (from-to)15-24
Number of pages10
Issue number1
StatePublished - Jan 9 2004

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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