Metabolic syndrome and risk factors for cardiovascular disease: Are nonagenarians protected?

Madlyn I. Frisard, Jennifer C. Rood, Xiaobing Fang, Joseph Su, David A. Welsh, S. Michal Jazwinski, Eric Ravussin

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


This study assessed cardiovascular disease risk factors in three groups of human subjects aged 20-34 [young, 20 male (M)/33 female (F)], 60-74 (aged, 29M/29F), and > 90 years (nonagenarian, 47M/50F). Components of the metabolic syndrome, cardiovascular disease, and markers of inflammation and oxidative stress were assessed. Nonagenarians weighed less than the two other groups (P∈<∈0.001); however, there was no difference in percent fat among the three groups. Aged individuals had the highest prevalence of the metabolic syndrome (P∈<∈0.001) according to the Adult Treatment Panel III classification. Both fibrinogen and homocysteine concentrations were significantly higher in the nonagenarians compared to younger groups. However, there were no significant differences between groups in fasting insulin, high sensitive C-reactive protein, and plasminogen activator inhibitor 1 concentrations. There were also no relationships between inflammation/ oxidative stress and the metabolic syndrome or cardiovascular disease although nonagenarians appear to be protected from oxidative damage to DNA.

Original languageEnglish (US)
Pages (from-to)67-75
Number of pages9
Issue number1
StatePublished - Mar 2009
Externally publishedYes


  • Aging
  • Cardiovascular disease
  • Inflammation
  • Metabolic syndrome
  • Oxidative stress

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology


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