@article{a0ce095d70114c5fac1e6c87d8b749a4,
title = "Metabolic strategies of melanoma cells: Mechanisms, interactions with the tumor microenvironment, and therapeutic implications",
abstract = "Melanomas are metabolically heterogeneous, and they are able to adapt in order to utilize a variety of fuels that facilitate tumor progression and metastasis. The significance of metabolism in melanoma is supported by growing evidence of impact on the efficacy of contemporary therapies for this disease. There are also data to support that the metabolic phenotypes of melanoma cells depend upon contributions from both intrinsic oncogenic pathways and extrinsic factors in the tumor microenvironment. This review summarizes current understanding of the metabolic processes that promote cutaneous melanoma tumorigenesis and progression, the regulation of cancer cell metabolism by the tumor microenvironment, and the impact of metabolic pathways on targeted and immune therapies.",
keywords = "glycolysis, melanoma, metabolism, oxidative phosphorylation, tumor microenvironment",
author = "Fischer, {Grant M.} and {Vashisht Gopal}, {Y. N.} and McQuade, {Jennifer L.} and Weiyi Peng and DeBerardinis, {Ralph J.} and Davies, {Michael A.}",
note = "Funding Information: G.M.F. is supported by the NIH National Center for Advancing Translational Sciences (TL1TR000369 and UL1TR000371). M.A.D. is supported by the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation and philanthropic contributions to the Melanoma Moon Shots Program of the University of Texas MD Anderson Cancer Center. M.A.D. and Y.N.V.G. are supported by the Cancer Prevention Research Institute of Texas (RP160183). M.A.D. and W.P. are supported by the NIH/NCI (R01 CA121118-06A1) and the Cancer Prevention Research Institute of Texas (RP170401). Funding Information: Y.N.V.G. is supported by Melanoma Research Alliance Young Investigator Award (348483). J.L.M. is supported by an ASCO/ CCF Young Investigator Award, an MDACC Melanoma SPORE Developmental Research Award (P50 CA093459), and an NIH T32 Training Grant Award (CA009666). R.J.D. is supported by the NIH/ NCI (R35 CA220449). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Publisher Copyright: {\textcopyright} 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",
year = "2018",
month = jan,
doi = "10.1111/pcmr.12661",
language = "English (US)",
volume = "31",
pages = "11--30",
journal = "Pigment Cell and Melanoma Research",
issn = "1755-1471",
publisher = "Wiley-Blackwell",
number = "1",
}