TY - JOUR
T1 - Metabolic regulation of mitochondrial dynamics
AU - Mishra, Prashant
AU - Chan, David C.
N1 - Funding Information:
This work was supported by grants from the National Institutes of Health (GM110039) and the Muscular Dystrophy Association.
Publisher Copyright:
© 2016 Newell-Litwa.
PY - 2016
Y1 - 2016
N2 - Mitochondria are renowned for their central bioenergetic role in eukaryotic cells, where they act as powerhouses to generate adenosine triphosphate from oxidation of nutrients. At the same time, these organelles are highly dynamic and undergo fusion, fission, transport, and degradation. Each of these dynamic processes is critical for maintaining a healthy mitochondrial population. Given the central metabolic function of mitochondria, it is not surprising that mitochondrial dynamics and bioenergetics reciprocally influence each other. We review the dynamic properties of mitochondria, with an emphasis on how these processes respond to cellular signaling events and how they affect metabolism.
AB - Mitochondria are renowned for their central bioenergetic role in eukaryotic cells, where they act as powerhouses to generate adenosine triphosphate from oxidation of nutrients. At the same time, these organelles are highly dynamic and undergo fusion, fission, transport, and degradation. Each of these dynamic processes is critical for maintaining a healthy mitochondrial population. Given the central metabolic function of mitochondria, it is not surprising that mitochondrial dynamics and bioenergetics reciprocally influence each other. We review the dynamic properties of mitochondria, with an emphasis on how these processes respond to cellular signaling events and how they affect metabolism.
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U2 - 10.1083/jcb.201511036
DO - 10.1083/jcb.201511036
M3 - Article
C2 - 26858267
AN - SCOPUS:84959516439
SN - 0021-9525
VL - 212
SP - 379
EP - 387
JO - Journal of Cell Biology
JF - Journal of Cell Biology
IS - 4
ER -