Metabolic fuel selection: The importance of being flexible

Research output: Contribution to journalReview articlepeer-review

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Studies in genetically engineered mice have shown the importance of cross-talk between organs in the regulation of energy metabolism. In this issue, a careful metabolic characterization of mice with genetic deficiency of the GLUT4 glucose transporter in adipocytes and muscle is reported (see the related article beginning on page 1666). These mice compensate for decreased peripheral glucose disposal by increasing hepatic glucose uptake and lipid synthesis as well as by increasing lipid utilization in peripheral tissues. These findings are relevant to humans with type 2 diabetes, in whom a key feature is diminished peripheral glucose disposal.

Original languageEnglish (US)
Pages (from-to)1547-1549
Number of pages3
JournalJournal of Clinical Investigation
Issue number11
StatePublished - Dec 2004

ASJC Scopus subject areas

  • Medicine(all)


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