TY - JOUR
T1 - Metabolic fuel selection
T2 - The importance of being flexible
AU - Bickel, Perry E.
PY - 2004/12
Y1 - 2004/12
N2 - Studies in genetically engineered mice have shown the importance of cross-talk between organs in the regulation of energy metabolism. In this issue, a careful metabolic characterization of mice with genetic deficiency of the GLUT4 glucose transporter in adipocytes and muscle is reported (see the related article beginning on page 1666). These mice compensate for decreased peripheral glucose disposal by increasing hepatic glucose uptake and lipid synthesis as well as by increasing lipid utilization in peripheral tissues. These findings are relevant to humans with type 2 diabetes, in whom a key feature is diminished peripheral glucose disposal.
AB - Studies in genetically engineered mice have shown the importance of cross-talk between organs in the regulation of energy metabolism. In this issue, a careful metabolic characterization of mice with genetic deficiency of the GLUT4 glucose transporter in adipocytes and muscle is reported (see the related article beginning on page 1666). These mice compensate for decreased peripheral glucose disposal by increasing hepatic glucose uptake and lipid synthesis as well as by increasing lipid utilization in peripheral tissues. These findings are relevant to humans with type 2 diabetes, in whom a key feature is diminished peripheral glucose disposal.
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U2 - 10.1172/JCI200423745
DO - 10.1172/JCI200423745
M3 - Review article
C2 - 15578087
AN - SCOPUS:15244340937
SN - 0021-9738
VL - 114
SP - 1547
EP - 1549
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 11
ER -