Metabolic Control of Cardiomyocyte Cell Cycle

Ivan Menendez-Montes; Daniel J. Garry; Jianyi Jay Zhang; Hesham A. Sadek

doi:10.14797/mdcvj.1309

Metabolic Control of Cardiomyocyte Cell Cycle

Ivan Menendez-Montes, Daniel J. Garry, Jianyi Jay Zhang, Hesham A. Sadek

Research output: Contribution to journal › Review article › peer-review

Abstract

Current therapies for heart failure aim to prevent the deleterious remodeling that occurs after MI injury, but currently no therapies are available to replace lost cardiomyocytes. Several organisms now being studied are capable of regenerating their myocardium by the proliferation of existing cardiomyocytes. In this review, we summarize the main metabolic pathways of the mammalian heart and how modulation of these metabolic pathways through genetic and pharmacological approaches influences cardiomyocyte proliferation and heart regeneration.

Original language	English (US)
Pages (from-to)	26-36
Number of pages	11
Journal	Methodist DeBakey cardiovascular journal
Volume	19
Issue number	5
DOIs	https://doi.org/10.14797/mdcvj.1309
State	Published - 2023

Keywords

cardiac regeneration
cardiomyocyte proliferation
glycolysis
oxidative phosphorylation
reactive oxygen species
uridine diphosphate N-acetylglucosamine (UDP GlycNAC)

ASJC Scopus subject areas

General Medicine

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10.14797/mdcvj.1309

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title = "Metabolic Control of Cardiomyocyte Cell Cycle",

abstract = "Current therapies for heart failure aim to prevent the deleterious remodeling that occurs after MI injury, but currently no therapies are available to replace lost cardiomyocytes. Several organisms now being studied are capable of regenerating their myocardium by the proliferation of existing cardiomyocytes. In this review, we summarize the main metabolic pathways of the mammalian heart and how modulation of these metabolic pathways through genetic and pharmacological approaches influences cardiomyocyte proliferation and heart regeneration.",

keywords = "cardiac regeneration, cardiomyocyte proliferation, glycolysis, oxidative phosphorylation, reactive oxygen species, uridine diphosphate N-acetylglucosamine (UDP GlycNAC)",

author = "Ivan Menendez-Montes and Garry, {Daniel J.} and Zhang, {Jianyi Jay} and Sadek, {Hesham A.}",

note = "Publisher Copyright: Copyright: {\textcopyright} 2023 The Author(s).",

year = "2023",

doi = "10.14797/mdcvj.1309",

language = "English (US)",

volume = "19",

pages = "26--36",

journal = "Methodist DeBakey cardiovascular journal",

issn = "1947-6094",

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T1 - Metabolic Control of Cardiomyocyte Cell Cycle

AU - Menendez-Montes, Ivan

AU - Garry, Daniel J.

AU - Zhang, Jianyi Jay

AU - Sadek, Hesham A.

PY - 2023

Y1 - 2023

N2 - Current therapies for heart failure aim to prevent the deleterious remodeling that occurs after MI injury, but currently no therapies are available to replace lost cardiomyocytes. Several organisms now being studied are capable of regenerating their myocardium by the proliferation of existing cardiomyocytes. In this review, we summarize the main metabolic pathways of the mammalian heart and how modulation of these metabolic pathways through genetic and pharmacological approaches influences cardiomyocyte proliferation and heart regeneration.

AB - Current therapies for heart failure aim to prevent the deleterious remodeling that occurs after MI injury, but currently no therapies are available to replace lost cardiomyocytes. Several organisms now being studied are capable of regenerating their myocardium by the proliferation of existing cardiomyocytes. In this review, we summarize the main metabolic pathways of the mammalian heart and how modulation of these metabolic pathways through genetic and pharmacological approaches influences cardiomyocyte proliferation and heart regeneration.

KW - cardiac regeneration

KW - cardiomyocyte proliferation

KW - glycolysis

KW - oxidative phosphorylation

KW - reactive oxygen species

KW - uridine diphosphate N-acetylglucosamine (UDP GlycNAC)

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U2 - 10.14797/mdcvj.1309

DO - 10.14797/mdcvj.1309

M3 - Review article

C2 - 38028975

AN - SCOPUS:85178649097

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VL - 19

SP - 26

EP - 36

JO - Methodist DeBakey cardiovascular journal

JF - Methodist DeBakey cardiovascular journal

IS - 5

ER -

Metabolic Control of Cardiomyocyte Cell Cycle

Abstract

Keywords

ASJC Scopus subject areas

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