Membrane phospholipid asymmetry: Host response to the externalization of phosphatidylserine

Elizabeth M. Bruckheimer; Alan J. Schroit

doi:10.1002/jlb.59.6.784

Membrane phospholipid asymmetry: Host response to the externalization of phosphatidylserine

Elizabeth M. Bruckheimer, Alan J. Schroit

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

Membrane phospholipid asymmetry is an important regulator of cellular function and homeostasis. The activities of lipid transporters are contributing factors to the regulation of membrane Lipid composition over the lifespan of the cell. Alterations in the activities of these proteins result in the movement of phosphatidylserine to the cell's outer leaflet. This promotes several physiologic responses including initiation of the coagulation cascade and cell recognition by the reticuloendothelial system.

Original language	English (US)
Pages (from-to)	784-788
Number of pages	5
Journal	Journal of Leukocyte Biology
Volume	59
Issue number	6
DOIs	https://doi.org/10.1002/jlb.59.6.784
State	Published - Jun 1996

Keywords

Erythrocytes
Lipid asymmetry
Macrophages

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Cell Biology

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10.1002/jlb.59.6.784

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title = "Membrane phospholipid asymmetry: Host response to the externalization of phosphatidylserine",

abstract = "Membrane phospholipid asymmetry is an important regulator of cellular function and homeostasis. The activities of lipid transporters are contributing factors to the regulation of membrane Lipid composition over the lifespan of the cell. Alterations in the activities of these proteins result in the movement of phosphatidylserine to the cell's outer leaflet. This promotes several physiologic responses including initiation of the coagulation cascade and cell recognition by the reticuloendothelial system.",

keywords = "Erythrocytes, Lipid asymmetry, Macrophages",

author = "Bruckheimer, {Elizabeth M.} and Schroit, {Alan J.}",

year = "1996",

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AU - Bruckheimer, Elizabeth M.

AU - Schroit, Alan J.

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N2 - Membrane phospholipid asymmetry is an important regulator of cellular function and homeostasis. The activities of lipid transporters are contributing factors to the regulation of membrane Lipid composition over the lifespan of the cell. Alterations in the activities of these proteins result in the movement of phosphatidylserine to the cell's outer leaflet. This promotes several physiologic responses including initiation of the coagulation cascade and cell recognition by the reticuloendothelial system.

AB - Membrane phospholipid asymmetry is an important regulator of cellular function and homeostasis. The activities of lipid transporters are contributing factors to the regulation of membrane Lipid composition over the lifespan of the cell. Alterations in the activities of these proteins result in the movement of phosphatidylserine to the cell's outer leaflet. This promotes several physiologic responses including initiation of the coagulation cascade and cell recognition by the reticuloendothelial system.

KW - Erythrocytes

KW - Lipid asymmetry

KW - Macrophages

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Membrane phospholipid asymmetry: Host response to the externalization of phosphatidylserine

Abstract

Keywords

ASJC Scopus subject areas

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