Membrane contact sites, gateways for lipid homeostasis

Sujoy Lahiri; Alexandre Toulmay; William A. Prinz

doi:10.1016/j.ceb.2014.12.004

Membrane contact sites, gateways for lipid homeostasis

Sujoy Lahiri, Alexandre Toulmay, William A. Prinz

Research output: Contribution to journal › Review article › peer-review

121 Scopus citations

Abstract

Maintaining the proper lipid composition of cellular membranes is critical for numerous cellular processes but mechanisms of membrane lipid homeostasis are not well understood. There is growing evidence that membrane contact sites (MCSs), regions where two organelles come in close proximity to one another, play major roles in the regulation of intracellular lipid composition and distribution. MCSs are thought to mediate the exchange of lipids and signals between organelles. In this review, we discuss how lipid exchange occurs at MCSs and evidence for roles of MCSs in regulating lipid synthesis and degradation. We also discuss how networks of organelles connected by MCSs may modulate cellular lipid homeostasis and help determine organelle lipid composition.

Original language	English (US)
Pages (from-to)	82-87
Number of pages	6
Journal	Current Opinion in Cell Biology
Volume	33
DOIs	https://doi.org/10.1016/j.ceb.2014.12.004
State	Published - Apr 1 2015
Externally published	Yes

ASJC Scopus subject areas

Cell Biology

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10.1016/j.ceb.2014.12.004

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title = "Membrane contact sites, gateways for lipid homeostasis",

abstract = "Maintaining the proper lipid composition of cellular membranes is critical for numerous cellular processes but mechanisms of membrane lipid homeostasis are not well understood. There is growing evidence that membrane contact sites (MCSs), regions where two organelles come in close proximity to one another, play major roles in the regulation of intracellular lipid composition and distribution. MCSs are thought to mediate the exchange of lipids and signals between organelles. In this review, we discuss how lipid exchange occurs at MCSs and evidence for roles of MCSs in regulating lipid synthesis and degradation. We also discuss how networks of organelles connected by MCSs may modulate cellular lipid homeostasis and help determine organelle lipid composition.",

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AU - Toulmay, Alexandre

AU - Prinz, William A.

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N2 - Maintaining the proper lipid composition of cellular membranes is critical for numerous cellular processes but mechanisms of membrane lipid homeostasis are not well understood. There is growing evidence that membrane contact sites (MCSs), regions where two organelles come in close proximity to one another, play major roles in the regulation of intracellular lipid composition and distribution. MCSs are thought to mediate the exchange of lipids and signals between organelles. In this review, we discuss how lipid exchange occurs at MCSs and evidence for roles of MCSs in regulating lipid synthesis and degradation. We also discuss how networks of organelles connected by MCSs may modulate cellular lipid homeostasis and help determine organelle lipid composition.

AB - Maintaining the proper lipid composition of cellular membranes is critical for numerous cellular processes but mechanisms of membrane lipid homeostasis are not well understood. There is growing evidence that membrane contact sites (MCSs), regions where two organelles come in close proximity to one another, play major roles in the regulation of intracellular lipid composition and distribution. MCSs are thought to mediate the exchange of lipids and signals between organelles. In this review, we discuss how lipid exchange occurs at MCSs and evidence for roles of MCSs in regulating lipid synthesis and degradation. We also discuss how networks of organelles connected by MCSs may modulate cellular lipid homeostasis and help determine organelle lipid composition.

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JO - Current Opinion in Cell Biology

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ER -

Membrane contact sites, gateways for lipid homeostasis

Abstract

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