TY - JOUR
T1 - Mei-P26 Cooperates with Bam, Bgcn and Sxl to Promote Early Germline Development in the Drosophila Ovary
AU - Li, Yun
AU - Zhang, Qiao
AU - Carreira-Rosario, Arnaldo
AU - Maines, Jean Z.
AU - McKearin, Dennis M.
AU - Buszczak, Michael
PY - 2013/3/20
Y1 - 2013/3/20
N2 - In the Drosophila female germline, spatially and temporally specific translation of mRNAs governs both stem cell maintenance and the differentiation of their progeny. However, the mechanisms that control and coordinate different modes of translational repression within this lineage remain incompletely understood. Here we present data showing that Mei-P26 associates with Bam, Bgcn and Sxl and nanos mRNA during early cyst development, suggesting that this protein helps to repress the translation of nanos mRNA. Together with recently published studies, these data suggest that Mei-P26 mediates both GSC self-renewal and germline differentiation through distinct modes of translational repression depending on the presence of Bam.
AB - In the Drosophila female germline, spatially and temporally specific translation of mRNAs governs both stem cell maintenance and the differentiation of their progeny. However, the mechanisms that control and coordinate different modes of translational repression within this lineage remain incompletely understood. Here we present data showing that Mei-P26 associates with Bam, Bgcn and Sxl and nanos mRNA during early cyst development, suggesting that this protein helps to repress the translation of nanos mRNA. Together with recently published studies, these data suggest that Mei-P26 mediates both GSC self-renewal and germline differentiation through distinct modes of translational repression depending on the presence of Bam.
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U2 - 10.1371/journal.pone.0058301
DO - 10.1371/journal.pone.0058301
M3 - Article
C2 - 23526974
AN - SCOPUS:84875149727
SN - 1932-6203
VL - 8
JO - PloS one
JF - PloS one
IS - 3
M1 - e58301
ER -