Medullary catecholaminergic neurons in the normal human brain and in Parkinson's disease

Clifford B. Saper, Denise M. Sorrentino, Dwight C. German, Sonsoles De Lacalle

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


Parkinson's disease is thought ot cause degeneration of melanin‐pigmented catecholaminergic neurons throughout the brainstem, but little quantitative information is available on the fate of catecholaminergic neurons associated with the dorsal vagal complex or medullary reticular formation. We therefore examined these neurons in the normal human medulla and in the brains of patients with Parkinson's disease, using both a melanin stain and immunohistochemical methods with an antiserum against tyrosine hydroxylase. The greatest numbers of catecholaminergic neurons in the ventrolateral reticular formation (A1/C1 group) were located in the far rostral medulla, whereas the largest populations of catecholaminergic cells in the dorsal vagal complex (A2/C2 group) were found at the level of the area postrema. No loss of cells was observed in the A1/C1 group in the parkinsonian brains. In contrast, the A2/C2 group showed moderate loss of neurons, most marked at the level of the area postrema. This difference was entirely due to the loss of neurons in the medial component of the A2 group, a population that normally is only lightly pigmented, while the heavily pigmented neurons in the ventral and intermediate components of the A2 complex were unaffected. Parkinson's disease causes degeneration only of selected populations of medullary catecholaminergic neurons, without apparent relationship to the extent of melanin pigmentation.

Original languageEnglish (US)
Pages (from-to)577-584
Number of pages8
JournalAnnals of Neurology
Issue number6
StatePublished - Jun 1991

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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