Medical therapy for pediatric vascular anomalies

Judith F. Margolin, Heather Mills Soni, Sheena Pimpalwar

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Vascular anomalies (VAs) comprise a large variety of individual diagnoses that in different phases of treatment require a diverse number of medical specialists to provide optimal care. Medical therapies include agents usually associated with cancer chemotherapy, such as vincristine, as well more immunomodulatory types of drugs, such as glucocorticoids and sirolimus. These immunomodulating drugs are being successfully applied in cases that are typically categorized as vascular tumors, including kaposiform hemangioendothelioma (KHE) and tufted angioma (TA), as well as some of the more invasive types of vascular malformations (i.e., microcystic lymphatic malformations and blue rubber bleb nevus syndrome (BRBNS). These therapies need to be combined with good supportive care, which often involves anticoagulation, antimicrobial prophylaxis, and comprehensive pain and symptom-relief strategies, as well as appropriate drug monitoring and management of side effects of medical treatment. The optimal care of these patients frequently involves close collaboration between surgeons, interventional and conventional radiologists, medical subspecialists, and nurses.

Original languageEnglish (US)
Pages (from-to)79-86
Number of pages8
JournalSeminars in Plastic Surgery
Issue number2
StatePublished - May 2014
Externally publishedYes


  • blue rubber bleb nevus syndrome
  • chemotherapy
  • kaposiform hemangioendothelioma
  • sirolimus
  • tufted angioma
  • vascular anomalies

ASJC Scopus subject areas

  • Surgery


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