@article{d9314269f5514e2c89494fcea0df329e,
title = "Medial temporal lobe functional connectivity predicts stimulation-induced theta power",
abstract = "Focal electrical stimulation of the brain incites a cascade of neural activity that propagates from the stimulated region to both nearby and remote areas, offering the potential to control the activity of brain networks. Understanding how exogenous electrical signals perturb such networks in humans is key to its clinical translation. To investigate this, we applied electrical stimulation to subregions of the medial temporal lobe in 26 neurosurgical patients fitted with indwelling electrodes. Networks of low-frequency (5–13 Hz) spectral coherence predicted stimulation-evoked increases in theta (5–8 Hz) power, particularly when stimulation was applied in or adjacent to white matter. Stimulation tended to decrease power in the high-frequency broadband (HFB; 50–200 Hz) range, and these modulations were correlated with HFB-based networks in a subset of subjects. Our results demonstrate that functional connectivity is predictive of causal changes in the brain, capturing evoked activity across brain regions and frequency bands.",
author = "Solomon, {E. A.} and Kragel, {J. E.} and R. Gross and Lega, {Bradley C} and Sperling, {M. R.} and G. Worrell and Sheth, {S. A.} and Zaghloul, {K. A.} and Jobst, {B. C.} and Stein, {J. M.} and S. Das and R. Gorniak and Inman, {C. S.} and S. Seger and Rizzuto, {D. S.} and Kahana, {M. J.}",
note = "Funding Information: We thank Blackrock Microsystems for providing neural recording equipment. This work was supported by the DARPA Restoring Active Memory (RAM) program (Cooperative Agreement N66001-14-2-4032), as well as National Institutes of Health grant MH55687 and T32NS091006. We are indebted to all patients who have selflessly volunteered their time to participate in our study. The views, opinions, and/or findings contained in this material are those of the authors and should not be interpreted as representing the official views or policies of the Department of Defense or the U.S. Government. We also thank Drs. Youssef Ezzyat, Christoph Weidemann, Nora Herweg, Danielle Bassett, and Geoffrey Aguirre for providing valuable feedback on this work. Data were provided in part by the Human Connectome Project, WU-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research; and by the McDonnell Center for Systems Neuroscience at Washington University. Publisher Copyright: {\textcopyright} 2018, The Author(s).",
year = "2018",
month = dec,
day = "1",
doi = "10.1038/s41467-018-06876-w",
language = "English (US)",
volume = "9",
journal = "Nature communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}